To determine the effect of ghrelin on placental cell proliferation, apoptosis and hormone secretion we cultured human JEG-3 cells with 100, 250, 500 or 1000 pg/ml of ghrelin for 48 hours. Ghrelin stimulated cell proliferation and decreased caspase-3 activity. All of the investigated ghrelin concentrations decreased progesterone (P(3)) but had no effect on human chorionic gonadotrophin (hCG) sec...

Methotrexate (MTX) is an accepted regimen for conservative treatment of unruptured ectopic pregnancy. However ,gestational sac greater than 3.5 cm, existence of cardiac activity and high titers of serum beta human chorionic gonadotrophin ( B-HCG) levels are relative contraindications of Mtx treatment. A 29-year-old, gravida 3, parity 1 and a 34-year-old nulliparous women presented with a compla...

Study population The parent study included women with an unruptured ectopic pregnancy, diagnosed by an algorithm using quantitative serum beta-human chorionic gonadotrophin (hCG) and transvaginal ultrasound, with or without a desire for future fertility. To be were eligible for the trial, the women had to have a serum beta-hCG concentration of less than 5,000 IU/L and an adnexal mass of less th...

BACKGROUND Human chorionic gonadotrophin (hCG) is measured in serum and urine for the early detection of ectopic pregnancy, patients with higher risk of miscarriage, embryos or fetuses with chromosome abnormalities, prediction of pre-eclampsia or fetal growth restriction and identification or follow-up of trophoblast neoplasia. This review examines basic knowledge on the heterogeneity of hCG pr...

The objective of this study was to evaluate the distribution of choriocarcinoma-like human chorionic gonadotrophin (HCG) isoforms during first trimester pregnancy and their relationship with in-vitro HCG bioactivity. This was done by means of a retrospective analysis of patients' sera with first trimester normal intrauterine and abnormal (ectopic) pregnancies. Serum samples were obtained from 3...

Vascular endothelial growth factor (VEGF) is stated to be a possible promoter of the development and the severity of ovarian hyperstimulation syndrome (OHSS). The secretion of VEGF in granulosa cells seems to be human chorionic gonadotrophin (HCG) dependent. In this prospective study, the data of 10 patients suffering from severe OHSS with ascites and pleural effusions (haematocrit, fluid balan...

We describe a case of choriocarcinoma with multiple organ metastases after term delivery. A 43-year-old female was diagnosed as choriocarcinoma with metastases to the liver, lungs, marrow cavity, thoracic vertebra and brain, based on serum levels of β-human chorionic gonadotrophin (β-hCG), clinical symptoms, gynecological examination, PET/CT examination and medical histories. Fourteen courses o...