In search of potential androgen receptor coregulators we performed a yeast two-hybrid screening using the androgen receptor ligand-binding domain as bait and a human prostate cDNA library as prey and found that the carboxy-terminal domain of retinoblastoma-associated Krüppel protein (RbaK), a member of the Krüppel zinc finger protein family, interacts in a ligand-dependent way with the ligand-b...

Triple-negative breast cancer (TNBC) is considered one of the most aggressive forms with poor survival rates compared to other subtypes. TNBC characterized by absence estrogen receptor alpha, progesterone receptor, and human epidermal growth factor 2, limiting those viable treatment options available patients Furthermore, due particularly high heterogeneity TNBC, conventional treatments such as...

The androgen receptor is an androgen-dependent transcription factor that belongs to the nuclear superfamily. When not bound its ligand, it mainly localized in cytoplasm, chaperone proteins, which stabilizes inactive conformation and confers a high affinity for ligand. conformational change of begins when molecule binds receptor, subsequently homodimerizes actively translocated nucleus. In nucle...

Sex differences are well known to be determinants of development, health and disease. Epigenetic mechanisms are also known to differ between men and women through X-inactivation in females. We hypothesized that epigenetic sex differences may also result from sex hormone functions, in particular from long-lasting androgen programming. We aimed at investigating whether inactivation of the androge...

Soft tissue artefact (STA) is caused by the relative displacement of markers or sensors mounted on the skin surface with respect to the underlying bones, and is a major source of error in the kinematic measurement of human movement. In particular, the humeral axial rotation (HAR) is affected by STA. The aim of this study was to propose a method for compensating for STA and to validate its effec...

Experiments with human prostate cancer cell lines have shown that forced overexpression of the ErbB2-receptor tyrosine kinase (RTK) promotes androgen-independent growth and increases androgen receptor-transcriptional activity in a ligand-independent fashion. To investigate the relationship between ErbB-RTK signaling and androgen in genetically unmanipulated human prostate cancer, we performed b...

Sex hormones and their receptors play a crucial role in human sexual dimorphism have been traditionally associated with hormone-dependent cancers like breast, prostate, endometrial cancer. However, recent research has broadened our understanding by revealing connections other types of cancers, such as lung cancer, where the androgen receptor found to be particularly significant. This review aim...

  Background and Objective: Determination of hormone receptor status in the management of breast cancer is well-established. The aim of this study was to evaluate the frequency of androgen receptor (AR) expression in invasive ductal carcinoma of breast. Materials and Methods: For this purpose, 55 cases of invasive ductal breast carcinoma were examined using a monoclonal antibody against AR on...

Aldose reductase (AR), an enzyme widely believed to be involved in the aberrant metabolism of glucose and development of diabetic complications, is expressed at low levels in the mouse. We studied whether expression of human AR (hAR), its inhibition with lidorestat, which is an AR inhibitor (ARI), and the presence of streptozotocin (STZ)-induced diabetes altered plasma fructose, mortality, and/...

Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in nonadherent cultures. Prostaspheres exhibited heterogeneous expression of proliferation, differentiation and stem cell associated makers CD44, ABCG2 and CD133. Treatment with WNT inhibitors reduced both prostasphere si...