Analysis of zoogeographic, paleogeographic, and molecular data has shown that the ancestors many fresh- brackish-water cold-tolerant hydrobionts Mediterranean region Danube River basin likely originated in East Asia or Central Asia. The fish genera Gasterosteus, Hucho, Oxynoemacheilus, Salmo, Schizothorax are examples these groups among vertebrates, Magnibursatus (Trematoda), Margaritifera, Pot...

The assembly of the four homologous, but distinct, a , b , g , and d subunits of the nicotinic acetylcholine receptor (nAChR) into the pentamer a 2 bgd presents a unique opportunity to delineate the individual amino acid side chains that contribute to the assembly process, and to examine the pathway responsible for subunit assembly and expression at the cell surface. It is well established that...

Nicotinic acetylcholine receptor (nAChR) is a pentameric receptor composed of four subunit types (a 2 , /?, y, 5) (Conti-Tronconi et al. 1982; Hucho 1986). Several studies have shown that the acetylcholine binding sites are localized on the and they can be inhibited by snake venom a-neurotoxin. Experimental results obtained with synthetic peptides and antibodies against a-subunit suggest that t...

Multhaup. Ferdinand Hucho, honorary chairman of the Luzie Fabisch Foundation, stated: ‘Luzie Fabisch donated to the Freie Universität Berlin a sizeable sum of money and dedicated it to ‘‘Cancer Research and Cellular Biology’’. To give the donation maximum impact, the university decided to set it aside for young, not yet settled researchers of the Department of Biology, Chemistry and Pharmacy, w...

A lipophilic photolabel, [3H] pyrenesulfonyl azide, has been synthesized and employed to detect which portions of the acetylcholine receptor (AcChR) molecule may be in contact with the hydrophobic environment of Torpedo californica electroplax membranes. The probe preferentially partitions into the hydrophobic regions of membrane lipids or Triton X100 micelles of detergent-solubilized membranes...

M-POS23 Castagna, M., Takai, Y., Kaibuchi, R., Sana, K., Kikkaw;), U . & Nishizuka, Y. (1982)J. Biol. Chem. 257, 7847-7851 Cohen, P., Burchell, A., Foulkes, J . G. & Cohcn, P. T. W. (1978) FEBS Lett. 92,287-293 Corbin, J . D., Sugden, P. H., West, L.. I:lockhart, I). A, , Lincoln, T. M. & McCarthy, D. (1978)J. Biol. Chem. 253, 3997-4003 Cori, G. T. & Cori, C. 1:. (1945)J. Biol. Chem. 158, 321 -...

Have you seen the recent papers that question the traditional role of B-type lamins in DNA replication and transcription, but highlight an entirely novel yet fundamental role for lamin B1 (LB1) in cell proliferation and cellular senescence? Lamins are the evolutionary progenitors of the intermediate filament superfamily, and constitute the building blocks of the nuclear lamina. They are also a ...