نتایج جستجو برای: hpv16 l1 vlp

تعداد نتایج: 35265  

2015
Karl T Kelsey Heather H Nelson Stephanie Kim Michael Pawlita Scott M Langevin Melissa Eliot Dominique S Michaud Michael McClean

BACKGROUND HPV infection is an established risk factor for oropharyngeal cancer, and it has been proposed that cigarette smoking may potentiate HPV infection in the oral epithelium. We sought to test the hypothesis that cigarette smoking increases HPV infection in an HPV16 serology study of cancer-free individuals. METHODS Subjects were participants in a risk factor study for head and neck ca...

2013
Asghar Abdoli Hoorieh Soleimanjahi Fatemeh Fotouhi Ali Teimoori Shahram Pour Beiranvand Zahra Kianmehr

OBJECTIVE(S) Infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. Recombinant DNA technology allows expression of the L1 major capsid protein of HPV in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (VLP). VLPS are non-infectious, highly immunogenic and can elicit neutralizing ant...

Journal: :Journal of virology 2003
Colin M Gelder O Martin Williams Keith W Hart Siôn Wall Gareth Williams Duncan Ingrams Peter Bull Mike Bunce Ken Welsh Sara E F Marshall Leszek Borysiewicz

Recurrent respiratory papillomatosis (RRP) is characterised by multiple laryngeal papillomas. Left untreated, the lesions enlarge, spread, and endanger the airway. Medical treatments are unsatisfactory, and repeated surgery remains the mainstay of therapy. RRP is caused by human papillomavirus (HPV) infection. However, since oral HPV infection is common and RRP is rare, other host and/or viral ...

Journal: :The Journal of biological chemistry 2003
Rongcun Yang William H Yutzy Raphael P Viscidi Richard B S Roden

Viruses that replicate in the nucleus, including the primary causative agent of cervical cancer, human papillomavirus type 16 (HPV16), must first cross the cytoplasm. We compared the uptake of HPV16 virus-like particles (VLPs) either with or without the minor capsid protein L2. Whereas VLPs containing only the major capsid protein L1 were diffusely distributed within the cytoplasm even 6 h post...

Journal: :International Journal of Molecular Sciences 2023

Persistent high-risk human papillomavirus (HPV) infection is a pivotal factor in the progression of cervical cancer. In recent years, an increasing interest has emerged comprehending influence HPV on head and neck squamous cell carcinoma (HNSCC). Notably, it well established that HPV-associated HNSCC show cases with distinct molecular clinical attributes compared to HPV-negative cases. The pres...

Journal: :Virology 2002
C Jane Dale Xiaosong Song Liu Robert De Rose Damian F J Purcell Jenny Anderson Yan Xu Graham R Leggatt Ian H Frazer Stephen J Kent

Vaccines to efficiently block or limit sexual transmission of both HIV and human papilloma virus (HPV) are urgently needed. Chimeric virus-like-particle (VLP) vaccines consisting of both multimerized HPV L1 proteins and fragments of SIV gag p27, HIV-1 tat, and HIV-1 rev proteins (HPV-SHIV VLPs) were constructed and administered to macaques both systemically and mucosally. An additional group of...

Journal: :World Journal Of Advanced Research and Reviews 2021

Human papillomavirus (HPV) infection is a leading cause of morbidity and mortality in women worldwide. The virus associated with benign warts broad spectrum malignancies, including cervical cancer, considered disease high clinical relevance, especially developing countries. In this study we developed the production recombinant proteins HPV16 L1 L2 human cells suspension (293-F), which were tran...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Jira Chansaenroj Apiradee Theamboonlers Pairoj Junyangdikul Sukumarn Swangvaree Anant Karalak Yong Poovorawan

The characterization of the whole genome of human papillomavirus type 16 (HPV16) from cervical cancer specimens with multiple infections in comparison with single infection samples as the oncogenic potential of the virus may differ. Cervical carcinoma specimens positive for HPV16 by PCR and INNO-LiPA were randomly selected for whole genome characterization. Two HPV16 single infection and six HP...

2017
Andrea Cerasuolo Clorinda Annunziata Marianna Tortora Noemy Starita Giovanni Stellato Stefano Greggi Maria Grazia Maglione Franco Ionna Simona Losito Gerardo Botti Luigi Buonaguro Franco M. Buonaguro Maria Lina Tornesello

Human papillomavirus type 16 (HPV16) is the major cause of cervical cancer and of a fraction of oropharyngeal carcinoma. Few studies compared the viral expression profiles in the two types of tumor. We analyzed HPV genotypes and viral load as well as early (E2/E4, E5, E6, E6*I, E6*II, E7) and late (L1 and L2) gene expression of HPV16 in cervical and oropharyngeal cancer biopsies. The study incl...

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