The purpose of the study was to prepare and evaluate clarithromycin (CLA) floating tablets using experimental mixture design for treatment of Helicobacter pylori provided by prolonged gastric residence time and controlled plasma level. Ten different formulations were generated based on different molecular weight of hypromellose (HPMC K100, K4M, K15M) by using simplex lattice design (a sub-class...

Kinetin is a highly potent growth factor that is capable of delaying or preventing age-related changes of human skin fibroblasts. The purpose of this study was to develop and characterize topical kinetin-loaded emulsion gel and liposome gel formulations. Emulsion formulation was prepared using the spontaneous emulsification method. Pseudoternary phase diagram for oil/water (o/w) type emulsion w...

In the present work Loratadine and Phenylephrine Bilayer tablets were prepared by compressing Loratadine layer as direct compressible layer which is an immediate release layer and Phenylephrine hydrochloride by wet granulation method as sustained release layer which are compressed using Bilayer tableting machine. The tablets were evaluated for thickness, hardness, friability, and weight variati...

Tizanidine hydrochloride is an orally administered prokinetic agent that facilitates or restores motility through-out the length of the gastrointestinal tract. The objective of the present investigation was to develop effervescent floating matrix tablets of tizanidine hydrochloride for prolongation of gastric residence time in order to overcome its low bioavailability (34-40 %) and short biolog...

The aim of the present study was to prepare mucoadhesive multiparticulate system for oral drug delivery using ionic gelation technique. Microspheres of different mucoadhesive polymers including hydroxypropyl methylcellulose (HPMC) K15M and carbopol 971P were prepared. In this technique cross linking of sodium alginate with calcium chloride was done which retarded the release of drug from the mu...

The aim of study was to prepare and characterize mucoadhesive buccal tablets of glipizide using different Mucoadhesive polymers such as Carbopol 940, Sodium alginate and HPMC K15M in combination. Twenty one formulation were developed with different concentration of mucoadhesive polymers in each formulation.The formulated buccal tablets were tested for surface pH,in vitro drug release and moistu...

The purpose of the study was to prolong the gastric residence time and increase the bioavailability of atenolol by designing its floating tablets and to study the influence of different polymers on its release rate. It was selected as a model drug, because it is poorly absorbed from the lower GIT. The tablets were prepared by direct compression technique, using different polymers such as hydrox...

Objectives: Carvedilol (CVD) is a nonselective β-adrenergic blocker that suffers from low absolute bioavailability (25-35%) due to first-pass metabolism. CVD-loaded buccal tablets were developed as a promising approach to overcome this limitation. Methods: The bilayers tablets were prepared by the direct compression technique. CVD-containing layer was based on one of four high molecular weight ...

Abstract: Objectives: Stavudine has a low half-life of 0.8-1.5 hr and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order enhance preserve the level stavudine for round clock, gastroretentive systems (floating low-density formulations that cause buoyancy on gastric fluid in stomach) may prove be advantageous releasing content from matrix tablet res...

INTRODUCTION The percolation theory studies the critical points or percolation thresholds of the system, where one component of the system undergoes a geometrical phase transition, starting to connect the whole system.The application of this theory to study the release rate of hydrophilic matrices allows to explain the changes in release kinetics of swellable matrix type system and results in a...