Identification of environmental hotspots becomes a pressing issue for companies pursuing sustainable supply chain management. In particular, excessive dependence on water resources outside the country may put the supply chain at unanticipated risk of water shortage. This article presents a practical approach to screening potential environmental hotspots of different impact categories that occur...

Somatic copy-number alterations (SCNAs) play a crucial role in the development of human cancer. However, it is not well understood what evolutionary mechanisms contribute to the global patterns of SCNAs in cancer genomes. Taking advantage of data recently available through The Cancer Genome Atlas, we performed a systematic analysis on genome-wide SCNA breakpoint data for eight cancer types. Fir...

Pattern detection is one of the essential challenges in crime mapping and analysis. Data mining can be used to explore crime detection problems. A cluster technique is an effective method for determining areas with high concentrations of localized events. Conversely, it remains a particularly demanding task to detect hotspots with mapping methods in view of the vulnerability connected with the ...

Identification of priority areas is a fundamental goal in conservation biology. Because of a lack of detailed information about species distributions, conservation targets in the Zhoushan Archipelago (China) were established on the basis of a species-area-habitat relationship (choros model) combined with an environmental cluster analysis (ECA). An environmental-distinctness index was introduced...

Integration of retroviral vectors in the human genome follows non random patterns that favor insertional deregulation of gene expression and may cause risks of insertional mutagenesis when used in clinical gene therapy. Understanding how viral vectors integrate into the human genome is a key issue in predicting these risks. We provide a new statistical method to compare retroviral integration p...

The unprecedented growth in mobile data usage is posing significant challenges to cellular operators. One key challenge is how to provide quality of service to subscribers when their residing cell is experiencing a significant amount of traffic, i.e. becoming a traffic hotspot. In this paper, we perform an empirical study on data hotspots in today’s cellular networks using a 9-week cellular dat...

Recombination events are not uniformly distributed and often cluster in narrow regions known as recombination hotspots. Several studies using different approaches have dramatically advanced our understanding of recombination hotspot regulation. Population genetic data have been used to map and quantify hotspots in the human genome. Genetic variation in recombination rates and hotspots usage hav...

Post-transcriptional regulation is regarded as one of the major processes involved in the regulation of gene expression. It is mainly performed by RNA binding proteins and microRNAs, which target RNAs and typically affect their stability. Recent efforts from the scientific community have aimed at understanding post-transcriptional regulation at a global scale by using high-throughput sequencing...