TaxishaveavitalroleinthetransportationsystemandInternetofVehicles(IoV)techniquescanbe usedtoimprovethefuelandtimeefficienciesoftaxis.However,theexistingworkdoesnotaddressthe trafficcongestionthatmayoccurwhenalargeamountoftaxisgathersincertainqueuingareas.This paperproposesanadaptiveandhotspot-awaretaxizonequeuingsystemtodealwithth...

DICER1, an endoribonuclease required for microRNA (miRNA) biogenesis, is essential for embryogenesis and the development of many organs including ovaries. We have recently identified somatic hotspot mutations in RNase IIIb domain of DICER1 in half of ovarian Sertoli-Leydig cell tumors, a rare class of sex-cord stromal cell tumors in young women. These hotspot mutations lost IIIb cleavage activi...

HotSpot Wizard is a web server for automatic identification of 'hot spots' for engineering of substrate specificity, activity or enantioselectivity of enzymes and for annotation of protein structures. The web server implements the protein engineering protocol, which targets evolutionarily variable amino acid positions located in the active site or lining the access tunnels. The 'hot spots' for ...

We present 85-GHz observations of the archetypal double-hotspot radio source 3C 20 made with the BIMA millimetre array. The resolution of BIMA allows us to separate the two components of the eastern hotspot. By comparing the BIMA observations with existing VLA data, we show that the spectra of the two hotspot components are very similar, despite the clear differences in their radio structure an...

We present 85-GHz observations of the archetypal double-hotspot radio source 3C 20 made with the BIMA millimetre array. The resolution of BIMA allows us to separate the two components of the eastern hotspot. By comparing the BIMA observations with existing VLA data, we show that the spectra of the two hotspot components are very similar, despite the clear differences in their radio structure an...

The Java HotSpot Server Compiler achieves improved asymptotic performance through a combination of ob− ject−oriented and classical−compiler optimizations. Aggressive inlining using class−hierarchy analysis reduces function call overhead and provides opportunities for many compiler optimizations.

The ade6-M26 mutation of the fission yeast Schizosaccharomyces pombe creates a meiotic recombination hotspot that elevates ade6 intragenic recombination approximately 10-15-fold. A heptanucleotide sequence including the M26 point mutation is required but not sufficient for hotspot activity. We studied the effects of plasmid and chromosomal context on M26 hotspot activity. The M26 hotspot was in...

We argue that wireless hotspot bandwidth can be exchanged as a peer-to-peer resource and we promote the idea of hotspot sharing, analogous to the traditional idea of file sharing. With hotspot sharing, users are encouraged to open their privately owned hotspots and offer Internet access to passersby. Payments are only “in kind” and not necessarily simultaneous. We are motivated by the widesprea...

Beginning with the adoption of the de-facto standard for wireless LAN communications IEEE 802.11 in 1999 we can observe a continuous growth of public wireless LAN hotspots that provide access to the Internet for modern road warriors. Unfortunately, current hotspots still suffer from several security drawbacks. In this paper we analyse how payment schemes used in current hotspot architectures co...

Increasingly, spatial geochemical zonation, present as geographically distinct, subparallel trends, is observed along hotspot tracks, such as Hawaii and the Galapagos. The origin of this zonation is currently unclear. Recently zonation was found along the last ∼70 Myr of the Tristan-Gough hotspot track. Here we present new Sr-Nd-Pb-Hf isotope data from the older parts of this hotspot track (Wal...