measurement of oxygenation is of great interest, because tumor oxygenation is an indicator of aggressiveness and affinity to metastazation [1]. Moreover, the chance of success of a radiation therapy or chemo therapy depends on the oxygen partial pressure of the tumorous tissue [2]. That is the reason why hypoxia is a large obstacle to tumor therapy [3]. In this study, a model of static dephasin...

PURPOSE Intramyocardial hemorrhage and area at risk are both prognostic markers in acute myocardial infarction (AMI). Myocardial T2 and T2 * mapping have been used to detect such tissue changes at 1.5T but these techniques are challenging at 3.0T due to additional susceptibility variation. We studied T2 and T2 * myocardial mapping techniques at 3.0T on a system employing B1 shimming and compare...

Background: Cardiac complications due to iron overload are the most common cause of death in patients with thalassemia major. The aim of this study was to compare iron chelation effects of deferoxamine, deferasirox, and combination of deferoxamine and deferiprone on cardiac and liver iron load measured by T2* MRI. Methods: In this study, 108 patients with thalassemia major aged over 10 years...

Introduction: Ultrashort echo time (UTE) MRI requires specialized pulse sequences to overcome the short T2 relaxation of the MR signal encountered in tissues such as ligaments, tendon or cortical bone. Imaging short T2 tissues is achieved in UTE by acquiring the Free Induction Decay (FID) of the MR signal as soon after the end of the RF excitation pulse as possible. This is typically accomplish...

Background: Iron-mediated cardiomyopathy is the main complication of thalassemia major (TM) patients. Therefore, there is an important clinical need in the early diagnosis and risk stratification of patients. The aim of this study was to evaluate the efficacy of tissue doppler imaging (TDI) to study cardiac iron overload in patients with TM using T2* magnetic resonance (MR) as the gold-standard...