Hot melt extrusion is one of the most popular techniques for manufacturing amorphous solid dispersions (ASDs). Over few decades, it has transitioned from lab scale to commercial with various products in market. The current review aims at summarizing considerations formulation development ASDs using HME. Various types Type I IV are discussed along state drug and polymeric carrier each type. Also...

Infectious disease outbreaks within healthcare facilities can exacerbate patient illness and, in some cases, be fatal. Contaminated surfaces and medical devices act as a reservoir for transmission of pathogens have been linked to the rising incidence healthcare-acquired infections. Antimicrobial reduce microbial contamination emerged crucial component infection control recent years. The aim thi...

Rectangular waveguide is one of the earliest types of transmission lines. Rectangular waveguide can be produced by hot extrusion process. In this paper, the hot extrusion process of CuZn5 rectangular waveguide was investigated by Finite Element Method (FEM). In addition, Genetic Algorithm (GA) was used to optimize the die geometry and process conditions to achieve the lowest magnitude of extrus...

The aim of this study was to develop a multilayer (core/coat) dosage form via co-extrusion, the core providing sustained drug release and the coat immediate drug release. In this study polymers were selected which can be combined in a co-extruded dosage form. Several thermoplastic polymers were hot-melt extruded and evaluated for processability and macroscopic properties (surface smoothness, di...

Fibrous filters were fabricated using a novel melt co-extrusion and two-dimensional multiplication technology combined with a high pressure water jet delamination technique. The filters made from polypropylene (PP) / polyamide 6 (PA6) system exhibited micro to nano scale fibers having uniform fiber distribution and superior mechanical properties. Effects of film draw ratio upon co-extrusion on ...

Aluminum matrix composites reinforced with Al2O3 and SiC particles (5 Vol%) were produced using the hot powder extrusion method. Extrusion temperature and extrusion reduction in area were chosen in the range of 500 to 600°C and 90 to 95%, respectively. The physical and mechanical properties of the extruded composites such as density, tensile strength, elongation and microhardness were evaluated...