The interactions among host immunity, pathogens, and environment are ever-going process of disease and health. In nature, there is an ongoing equilibrium between infectious agents and their susceptible host organisms. While challenge of immune-competent individuals to low pathogenic strains usually results in elimination of the infectious agent, the other host-pathogen matches generally produce...

the worldwide prevalence of insulin resistant states such as the metabolic syndrome has grown rapidly over the past few decades. the metabolic syndrome is a constellation of common metabolic disorders that promote the development of atherosclerosis and cardiovascular disease. studies in both human and animal models suggest that hepatic inflammation and insulin resistance are key initiating fact...

A longstanding and still-increasing threat to the effective treatment of infectious diseases is resistance to antimicrobial countermeasures. Potentially, the targeting of host proteins and pathways essential for the detrimental effects of pathogens offers an approach that may discover broad-spectrum anti-pathogen countermeasures and circumvent the effects of pathogen mutations leading to resist...