نتایج جستجو برای: hops

تعداد نتایج: 3627  

2011
Lukas Krämer Christian Ungermann

Membrane fusion within the endomembrane system follows a defined order of events: membrane tethering, mediated by Rabs and tethers, assembly of soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE) complexes, and lipid bilayer mixing. Here we present evidence that the vacuolar HOPS tethering complex controls fusion through specific interactions with the vacuolar SN...

2017
Amy Orr Hongki Song Scott F. Rusin Arminja N. Kettenbach William Wickner

Rab GTPases, their effectors, SNAREs of the R, Qa, Qb, and Qc families, and SM SNARE-binding proteins catalyze intracellular membrane fusion. At the vacuole/lysosome, they are integrated by the homotypic fusion and vacuole protein sorting (HOPS) complex. Two HOPS subunits bind vacuolar Rabs for tethering, another binds the Qc SNARE, and a fourth HOPS subunit, an SM protein, has conserved groove...

Journal: :Journal of cell science 2005
Maria Agnese Della Fazia Marilena Castelli Daniela Bartoli Stefania Pieroni Valentina Pettirossi Danilo Piobbico Mariapia Viola-Magni Giuseppe Servillo

The liver has the ability to autonomously regulate growth and mass. Following partial hepatectomy, hormones, growth factors, cytokines and their coupled signal transduction pathways have been implicated in hepatocyte proliferation. To understand the mechanisms responsible for the proliferative response, we studied liver regeneration by characterization of novel genes that are activated in resid...

Journal: :Alcohol and alcoholism 2017
Marianne Landmann Cathrin Sellmann Anna Janina Engstler Doreen Ziegenhardt Finn Jung Christine Brombach Ina Bergheim

AIM Using a binge-drinking mouse model, we aimed to determine whether hops (Humulus lupulus) in beer is involved in the less damaging effects of acute beer consumption on the liver in comparison with ethanol. METHODS Female C57BL/6 J mice were either fed one iso-alcoholic and iso-caloric bolus dose of ethanol, beer, beer without hops (6 g ethanol/kg body weight) or an iso-caloric bolus of mal...

Journal: :PLoS ONE 2008
Hyunjeong Yang Hiroshi Takagi Yoshiyuki Konishi Hiroshi Ageta Koji Ikegami Ikuko Yao Showbu Sato Ken Hatanaka Kaoru Inokuchi Dae-Hyun Seog Mitsutoshi Setou

Some ubiquitin-like (UBL) domain-containing proteins are known to play roles in receptor trafficking. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) undergo constitutive cycling between the intracellular compartment and the cell surface in the central nervous system. However, the function of UBL domain-containing proteins in the recycling of the AMPARs to the synap...

2015
Divya Khatter Vivek B. Raina Devashish Dwivedi Aastha Sindhwani Surbhi Bahl Mahak Sharma

The homotypic fusion and protein sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome and lysosome fusion. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Here, we report that the small GTPase Arl8b, but not Rab7 (also known as RAB7A), is essential for membrane localization of the human (...

Journal: :Molecular biology of the cell 2009
Cortney G Angers Alexey J Merz

Adaptor protein complexes (APs) are evolutionarily conserved heterotetramers that couple cargo selection to the formation of highly curved membranes during vesicle budding. In Saccharomyces cerevisiae, AP-3 mediates vesicle traffic from the late Golgi to the vacuolar lysosome. The HOPS subunit Vps41 is one of the few proteins reported to have a specific role in AP-3 traffic, yet its function re...

2014
Seyed Hassan Hejazian Seyyed Majid Bagheri Mohammad Hossein Dashti-R

OBJECTIVE Many biological studies have been done to determine the activity of medicinal plants on gastrointestinal function. Since acetylcholine is the major transmitter involved in the gastrointestinal motility and there are some evidences regarding the cholinergic modulatory effect of hops extract, in the present study spasmolytic and antispasmodic action of hops (Humulus lupulus) on acetylch...

Journal: :The Journal of biological chemistry 2014
Heide Behrmann Anna Lürick Anne Kuhlee Henning Kleine Balderhaar Cornelia Bröcker Daniel Kümmel Siegfried Engelbrecht-Vandré Ulrich Gohlke Stefan Raunser Udo Heinemann Christian Ungermann

Membrane fusion at the vacuole, the lysosome equivalent in yeast, requires the HOPS tethering complex, which is recruited by the Rab7 GTPase Ypt7. HOPS provides a template for the assembly of SNAREs and thus likely confers fusion at a distinct position on vacuoles. Five of the six subunits in HOPS have a similar domain prediction with strong similarity to COPII subunits and nuclear porins. Here...

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