High costs, unreliable resources for long term use and extensive negative impact on our environment are such problems associated with traditional sources of energy and fossil fuels which make us move toward implementation of renewable sources of energy. Fossil fuel pollution and reserve depletion in oil producing countries caused by increasing demands, make wind energy an attractive source of e...

Homers are scaffolding proteins that bind G protein-coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs), ryanodine receptors, and TRP channels. However, their role in Ca2+ signaling in vivo is not known. Characterization of Ca2+ signaling in pancreatic acinar cells from Homer2-/- and Homer3-/- mice showed that Homer 3 has no discernible role in Ca2+ signaling in these...

Abstract The purpose of this study is to design a Photovoltaics (PV) stand-alone system for residential load in Bunaken Island using HOMER (Hybrid Optimization Multiple Energy Resources). Island, the case location, popular tourist spot North Sulawesi, Indonesia. This island facing issue limited access electrical energy from grid. and techno-economic analysis leveraged software. software was dev...

Optimal dispatch is a major concern in the optimization of hybrid energy systems (HESs). Efficient and effective models that satisfy load demand at minimum net present cost (NPC) are crucial because high capital costs renewable technologies. The algorithms native to multiple resources (HOMER) software, cycle-charging (CC) load-following (LF), powerful for modeling optimizing HESs. In these cont...

Homer is a crucial postsynaptic scaffolding protein involved in both maintenance and activity-induced plasticity of the synapse. However, its quaternary structure has yet to be determined. We conducted a series of biophysical experiments that provide the first evidence that Homer forms a tetramer via its coiled-coil domain, in which all subunits are aligned in parallel orientation. To test the ...

Understanding the impacts of recreational fishing on habitats and species, as well as the social and ecological importance of place to anglers, requires information on the spatial distribution of fishing activities. This study documented long-term changes in core fishing areas of a major recreational fishery in Alaska and identified biological, regulatory, social, and economic drivers of spatia...

in this paper, optimal design of hybrid solar-wind- diesel energy system with battery storage for reliable load in arsoon village in ardabil is presented. the village has 35 households that mean daily energy consumption is estimated 63.4 kwh. in this design optimization is implemented, considering loss of power supply probability (lpsp) index for reliable load providing, with minimum total cons...

The postsynaptic density (PSD) proteins Shank and Homer cooperate to induce the maturation and enlargement of dendritic spines (Sala et al., 2001). Homer1a is an activity-inducible short-splice variant of Homer that lacks dimerization capacity. Here, we show that Homer1a reduces the density and size of dendritic spines in cultured hippocampal neurons in correlation with an inhibition of Shank t...

Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), the cause of which is poorly understood. Here, we identified the unique proteomic signature of Sca1(154Q/2Q) PCs at an early stage of disease, highlighting extensive alterations in proteins associate...

Sleep is an evolutionarily conserved process that is linked to diurnal cycles and normal daytime wakefulness. Healthy sleep and wakefulness are integral to a healthy lifestyle; this occurs when an organism is able to maintain long bouts of both sleep and wake. Homer proteins, which function as adaptors for group 1 metabotropic glutamate receptors, have been implicated in genetic studies of slee...