Malignant melanoma is the major cause of skin cancer-related deaths. Surgery in combination with radiotherapy, immunotherapy or chemotherapy used to eradicate cancer cells, however, this treatment option limited by tolerance surrounding healthy tissue. The extracts from Galenia africana have been shown possess anti-cancer flavonoid compounds and can be a safer cost-effective alternative treatme...

Fenbendazole (FBZ) is a commonly used anthelmintic in veterinary medicine that has recently been found to have anticancer effects humans. On the other hand, few studies examined anti-inflammatory of FBZ, and its mechanism unknown. In this study, mouse bone marrow cells (BMs) were treated with lipopolysaccharide (LPS), representative inflammation-inducing substance, generate situation similar os...

Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we investigated interactions of five CDKi (purvalanol A, olomoucine II, roscovitine, flavopiridol and SNS-032) with the ABCB1 transporter. Four o...

Objective: This study was to investigate the role of Chloride Channel-3 (ClC-3) in apoptosis of primary rat hippocampal neurons. Methods: SIN-1 (3-morpholinosyndomine), a nitric oxide donor, was used to induce apoptosis in the hippocampal neurons. The cell viability was assessed by the MTT (3-(4, 5-Dimethythiazol-2 yl)diphenytetra zolium bromide) assay. Hoechst 33342 staining was performed to d...