نتایج جستجو برای: hmsc
تعداد نتایج: 602 فیلتر نتایج به سال:
The intracellular signaling events controlling human mesenchymal stem cells (hMSC) differentiation into osteoblasts are not entirely understood. We recently demonstrated that contact with extracellular matrix (ECM) proteins is sufficient to induce osteogenic differentiation of hMSC through an ERK-dependent pathway. We hypothesized that FAK signaling pathways provide a link between activation of...
The ITU standard for MSCs provides a useful framework for visualizing communication protocols. HMSCs can describe a collection of MSC scenarios in early stages of system design. They extend nite state systems by partial order semantics and asynchronous, unbounded message exchange. Usually we ask whether an HMSC can be implemented, for instance by a nite state protocol. This question has been sh...
BACKGROUND Although human mesenchymal stem cells (hMSCs) have been tested in ischemic cardiomyopathy, few studies exist in chronic nonischemic dilated cardiomyopathy (NIDCM). OBJECTIVES The authors conducted a randomized comparison of safety and efficacy of autologous (auto) versus allogeneic (allo) bone marrow-derived hMSCs in NIDCM. METHODS Thirty-seven patients were randomized to either ...
Interferon gamma (IFNγ) is a strong inhibitor of osteoclast differentiation and activity. However, its role in osteoblastogenesis has not been carefully examined. Using microarray expression analysis, we found that several IFNγ inducible genes were upregulated during early phases of osteoblast differentiation of human mesenchymal stem cells (hMSC). We therefore hypothesized that IFNγ may play a...
The impact of human adult ischemia-tolerant mesenchymal stem cells (hMSCs) and factors (stem cell factors) on cerebral amyloid beta (Aβ) pathology was investigated in a mouse model of Alzheimer's disease (AD). To this end, hMSCs were administered intravenously to APPPS1 transgenic mice that normally develop cerebral Aβ. Quantitative reverse transcriptase polymerase chain reaction biodistributio...
Lactococcus lactis, a non-pathogenic bacteria, has been genetically engineered to express the III7-10 fragment of human fibronectin as a membrane protein. The engineered L. lactis is able to develop biofilms on different surfaces (such as glass and synthetic polymers) and serves as a long-term substrate for mammalian cell culture, specifically human mesenchymal stem cells (hMSC). This system co...
Lateral integration and fusion of cartilage tissue interfaces remain significantly challenging limits success engineering (TE) strategies. In this study, self-assembled vitreous humor (VH) spheroids are fabricated by seeding clinically relevant human articular chondrocytes (hACs) or mesenchymal stromal cells (hMSCs) in four VH hydrogels with different glycosaminoglycans (GAG) protein content. Q...
BACKGROUND Acquisition of a blood supply is fundamental for extensive tumor growth. We recently described vascular heterogeneity in tumours derived from cell clones of a human mesenchymal stem cell (hMSC) strain (hMSC-TERT20) immortalized by retroviral vector mediated human telomerase (hTERT) gene expression. Histological analysis showed that cells of the most vascularized tumorigenic clone, -B...
BACKGROUND There have been conflicting observations regarding the receptors utilized by human multipotent mesenchymal bone marrow stromal cells (hMSC) to adhere to endothelial cells (EC). To address the discrepancies, we performed experiments with cells prepared with a standardized, low-density protocol preserving a sub-population of small cells that are rapidly self-renewing. METHODS Sialyl ...
Objectives: Osteopenia is frequent in HIV-infected patients treated with antiretroviral therapy (ART) and has been linked to increased osteoclastogenesis. Little known about the effects of ART on osteogenesis. Design: We investigated effect human mesenchymal stem cells (hMSC) osteoblasts Darunavir Dolutegravir, most highly used as anchor drugs within a three-drug regimen, Atazanavir, which was ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید