HM-3, designed by our laboratory, is a polypeptide composed of 18 amino acids. Pharmacodynamic studies in vivo and in vitro indicated that HM-3 could inhibit endothelial cell migration and angiogenesis, thereby inhibiting tumor growth. However, the half-life of HM-3 is short. In this study, we modified HM-3 with different polyethylene glycols (PEG) in order to reduce the plasma clearance rate, ...

In this study, harmine liposomes (HM-lip) were prepared through the thin-film hydration-pH-gradient method and then coated with N-trimethyl chitosan (TMC). Particle size, zeta potential, entrapment efficiency, and in vitro release of HM-lip and TMC-coated harmine liposomes (TMC-HM-lip) were also determined. Sprague Dawley rats were further used to investigate the pharmacokinetics in vivo. Reten...

Human milk (HM) contains a plethora of metabolic hormones, including leptin, which is thought to participate in the regulation of the appetite of the developing infant. Leptin in HM is derived from a combination of de novo mammary synthesis and transfer from the maternal serum. Moreover, leptin is partially lipophilic and is also present in HM cells. However, leptin has predominately been measu...

Given a sequence (Xn) of random variables, Xn is said to be near-record if Xn∈(Mn−1−a,Mn−1], where Mn=max{X1, …, Xn} and a>0 parameter. We investigate the point process η on [0,∞) values from an integer-valued, independent identically distributed sequence, showing that it Bernoulli cluster process. derive probability generating functional formulas for expectation, variance covariance countin...

in present work, we have calculated the electronic properties including density of states and electron density for gan, inn and inxga1-xn  in wurtzite phase for x=0.5. the study is based on density functional theory with full potential linearized augmented plane wave method by generalized gradient approximation for calculating electronic properties. in this report we concluded that inxga1-xn ba...

A novel trinuclear cobalt(III) phosphate complex, {[Co(en)2]3(PO4)(HPO4)}2(H2PO4)Cl7 Æ 6H2O, has been synthesized and characterized by single crystal X-ray structure determination and NMR spectroscopy. The compound includes an unprecedented type of discrete cluster with three metal atoms bridged by two phosphate anions. The clusters are associated in chains by strong hydrogen bonds PO4 H PO4. T...

Some algorithms for nding common xed point of a family of mappings isconstructed. Indeed, let C be a nonempty closed convex subset of a uniformlyconvex Banach space X whose norm is Gateaux dierentiable and let {Tn} bea family of self-mappings on C such that the set of all common fixed pointsof {Tn} is nonempty. We construct a sequence {xn} generated by the hybridmethod and also we give the cond...