Genes located outside the HLA region (6p21) have been considered as candidates for susceptibility to ankylosing spondylitis. We tested the hypothesis that the G22A polymorphism of the adenosine deaminase gene (ADA; 20q13.11) is associated with ankylosing spondylitis in 166 Brazilian subjects genotyped for the HLA*27 gene (47 patients and 119 controls matched for gender, age and geographic ...

Background: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the inhabitants of many regions. Objective: To define the frequency of HLA alleles and haplotypes am...

multiple sclerosis (ms) is an inflammatory demyelinating disease of the central nervous system. it is a clinically heterogeneous disorder especially in terms of disease severity. current investigations suggest that genes and gene-gene interactions not only influence on susceptibility to ms but also affect the disease severity. in this study, we investigated the contribution of the hladrb1*1501 ...

background and objective: the outcome of hepatitis b virus (hbv) infection may be influenced by host factors like human leukocyte antigen (hla). we have investigated hla-a and drb1 alleles in patients with persistent hepatitis b infection compared to subjects who had spontaneously recovered from hbv infection. to complete the findings of this study we performed another survey in certain hla all...

BACKGROUND End-Stage Renal Disease (ESRD) is a worldwide public health problem. Currently, many genome-wide association studies have suggested a potential association between human leukocyte antigen (HLA) and ESRD by uncovering a causal relationship between HLA and glomerulonephritis. However, previous studies, which investigated the HLA polymorphism and its association with ESRD, were performe...

Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB). The association between HBV infection and human leukocyte antigen- (HLA-) DQ polymorphism (rs2856718 and rs7453920) has been demonstrated in other studies; however, the results were controversial or inconclusive. Therefore, to derive a more precise estimation of the association, a meta-analysis was p...

Introduction: Diffuse Large B- cell Lymphoma (DLBCL) is characterized by genetic and clinical heterogeneity. Different loci within the human leukocyte antigen (HLA) region have been implicated in susceptibility disease control of DLBCL. Methods: HLA typing was performed using Sequence-Specific Oligonucleotide (SSO) Primer (SSP) 60 DLBCL patients 250 healthy adult donors from local Bone Marrow r...

The major histocompatibility complex is directly involved in the immune response, and thus genes coding for its proteins are useful markers study of genetic diversity, susceptibility to disease (autoimmunity infections), transplant medicine, pharmacogenetics, among others. polymorphism system also allows researchers use it as a proxy population genetics analysis, such admixture structure. In or...

The HLA class I polymorphism was studied in a sample of the Albanian population. Ninety-three unrelated healthy Albanians were typed for HLA-A, -B and -Cw antigens by standard microlyphocytotoxicity test. The antigens with the highest frequencies were: HLA-A2 (34.4%), A3 (14.5%) and A1 (12.4%); B51 (19.3%), B35 (12.4%) and B18 (10.2%); Cw4 (16.2%), Cw7 (16.2%) and Cw6 (10.8%). The HLA haplotype...