using a standard microcytotoxicity (nih) technique of tissue typing, the hla-b27 antigen was identified in 30 out of 34 patients (hh.2%) with classical ankylosing spondylitis (as), compared to 6 out of 70 controls (h.6%) (p < 0.005). we also found this antigen in 8 out of 76 (10.5%) patients with non-as arthritis.

A murine monoclonal antibody directed against a human B cell surface antigen with the characteristics of HLA-DR is described. The antigen detected is tightly linked to HLA and is correlated with the alloantigen HLA-Dw/DR3. Reactivity with a fraction of Dw/DRw6 cells is also observed. The determinant recognized by this antibody has been shown to be present on the smaller molecular weight beta su...

The influence of HLA-DR antigen matching in 70 cadaver transplants was studied for up to four years. The overall cumulative renal graft survival at one year was 62 percent, and at two and four years it was 60 percent. The one, two, and four year cumulative graft survival for patients receiving one or two HLA-DR antigen matched grafts was 74 percent, 69 percent, and 69 percent, respectively. In ...

Background: Human leukocyte antigen (HLA) gene is a highly polymorphic region. HLA typing is required to&nbsp;match&nbsp;patients and donors for transplantation; therefore, development of HLA registries is necessary for finding HLA match donors. HLA system is highly informative, and numerous studies have been conducted on HLA allele distribution in different populations. Methods: In this study,...

PURPOSE To compare outcomes of bone marrow transplants for leukemia from HLA-identical siblings, haploidentical HLA-mismatched relatives, and HLA-matched and mismatched unrelated donors. PATIENTS A total of 2,055 recipients of allogeneic bone marrow transplants for chronic myelogenous leukemia (CML), acute myelogenous leukemia (AML), and acute lymphoblastic leukemia (ALL) were entered onto th...

We have investigated the role of antigen-processing machinery (APM) component defects in HLA class I antigen down-regulation in laryngeal squamous cell carcinoma (SCC) lesions and assessed the clinical significance of these defects. To this end, 63 formalin-fixed, paraffin-embedded tumor lesions were examined for APM component and HLA class I antigen expression by immunohistochemistry. Calnexin...

We have investigated the role of antigen-processing machinery (APM) component defects in HLA class I antigen downregulation in laryngeal squamous cell carcinoma (SCC) lesions and assessed the clinical significance of these defects. To this end, 63 formalin-fixed, paraffin-embedded tumor lesions were examined for APM component and HLA class I antigen expression by immunohistochemistry. Calnexin,...

Abstract Major histocompatibility (MHC) bound viral peptides are the immune signatures to initiate selective and cross-reactive T cell responses. Identifying antigenic targets of adaptive immunity SARS-CoV-2 is a key towards understanding pathogenesis Sars-CoV-2 rapidly evolving mutants. We isolated immunopeptidomes identify naturally processed presented MHC-II (HLA-DR, HLA-DP) MHC-I (HLA-ABC) ...