Epidermodysplasia verruciformis (EV) is triggered by a variety of mechanisms that at least partly include genetic background. We present a Brazilian man with a 30-year history of flat, wart-like lesions with clinical, histopathological, and evolutive aspects consistent with papillomavirus (HPV)-associated EV. Histological analysis of the wart lesions showed epidermis with hyperkeratosis, regula...

nism underlying narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and abnormal REM sleep, remains elusive, one of the susceptibility factor, HLADQB1*0602, has now been identified. Subjects homozygous or heterozygous for this HLA-DQB1 allele are at much greater risk of developing narcolepsy than subjects without this antigen. DNA sequencing studies, family studies and tr...

Donor-specific antibodies (DSA) in sera of sensitized transplant patients are often produced against the specific epitopes on mismatched HLA antigens. In this study, we selected sera from 30 kidney transplant patients with DSA and AMR to define DQ epitopes. Using adsorption and elution assays, we identified 18 antibody reaction patterns to define 6 new epitopes and to confirm 12 previously defi...

The advance of semantic web and e-learning technologies has provided more opportunities to achieve the goal of collaborative knowledge sharing. It has also facilitated teachers to share their teaching material, tools, and experiences with others through the medium of internet and web technologies. In an earlier paper, we proposed the need for creating a Distributed Question Bank (DQB) by differ...

Genetic variation plays a significant role in maintaining the evolutionary potential of a species. Comparing the patterns of adaptive and neutral diversity in extant populations is useful for understanding the local adaptations of a species. In this study, we determined the fine-scale genetic structure of 6 extant populations of the giant panda (Ailuropoda melanoleuca) using mtDNA and DNA finge...