نتایج جستجو برای: hla dq b1
تعداد نتایج: 61570 فیلتر نتایج به سال:
Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous class II molecules to study the interaction between the DR and DQ molecules and define the immunologic mechanisms in rheumatoid arthritis. Using collagen-induced arthritis (CIA) as an experimental mo...
Objectives: Despite the improvements in early-term outcomes of kidney transplantation, late-term graft failure still remained as a critical problem. De novo donor specific antibodies (DSA) developing against direct human leukocyte antigens (HLA) are significant risk factors for shortened survival previously non-sensitized cases. The purpose this study is to evaluate clinical de DSA development ...
کمپلکس اصلی سازگاری بافتی(MHC)، یک قسمت از ژنوم است که نقش اساسی در بروز پاسخ ایمنی نسبت به آنتی ژن های پروتئینی ایفا می کنند و در بازوی کوتاه کروموزوم 6 واقع شده است که در انسان این کمپلکس را تحت عنوان آنتی ژن های لکوسیتی انسان (HLA) می شناسند. HLA بر اساس ساختمان توزیع بافتی و عملکرد به سه ناحیه مشخص کلاس I (دارای جایگاه A، B و C)، HLA کلاس II (DR, DQ, DP) و کلاس III تقسیم می شود. بررسی های...
Analysis of sequence variation in the polymorphic second exon of the major histocompatibility complex genes HLA-DQ alpha and -DQ beta has revealed 8 allelic variants at the alpha locus and 13 variants at the beta locus. Correlation of sequence variation with serologic typing suggests that the DQw2, DQw3, and DQ(blank) types are determined by the DQ beta subunit, while the DQw1 specificity is de...
BACKGROUND Changing perspectives on the natural history of celiac disease (CD), new serology and genetic tests, and amended histological criteria for diagnosis cast doubt on past prevalence estimates for CD. We set out to establish a more accurate prevalence estimate for CD using a novel serogenetic approach. METHODS The human leukocyte antigen (HLA)-DQ genotype was determined in 356 patients...
background: pulmonary tuberculosis (pt) is one of the endemic diseases in iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (hla) system. we sought to investigate the association between hla-class i (a and b) and -class ii (dr and dq) alleles in a sample of pt iraqi patients. methods: lymphocytes of 105 pt patients and 40 controls were phenotyped for ...
The HLA class II molecules of the human MHC are cell surface glycoproteins that play a critical role in the immune response regulation . At least three HLAclass II isotypes have been described (HLA-DR, -DQ, and -DP), each composed of an a and a ß chain (1) . In addition to conventional HLA class II molecules, the existence of hybrid molecules formed by transcomplementation (hybrid HLA-DQ) and i...
Background Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the involvement of multiple organs and autoantibody production. This study aimed to determine association human leukocyte antigen (HLA)-DQ -DR alleles with SLE at tertiary hospital in Bangladesh. Methods case–control was conducted Department Rheumatology, Bangabandhu Sheikh Mujib Medical University (...
The association of specific HLA-DQ alleles with autoimmunity is correlated with discrete polymorphisms in the HLA-DQ sequence that are localized within sites suitable for peptide recognition. The polymorphism at residue 57 of the DQB1 polypeptide is of particular interest since it may play a major structural role in the formation of a salt bridge structure at one end of the peptide-binding clef...
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