A key role for histamine in the physiological control of gastric acid secretion was established with the advent of the histamine H2-receptor antagonists which have in vivo been shown to inhibit virtually all forms of basal and stimulated secretion.' These data can be seen to support the common mediator hypothesis championed in the last three decades by Code2 3 and which states that secretory st...

Background Uteroglobin (CC10) is well known to be an immuno-suppressive protein secreted from airway epithelial cells after inflammatory stimulation and function in development of allergic disorders. Although histamine H1 receptor antagonists are used for the treatment of allergic disorders, the influence of the agents on CC10 production is not well understood. In the present study, we examined...

A key role for histamine in the physiological control of gastric acid secretion was established with the advent of the histamine H2-receptor antagonists which have in vivo been shown to inhibit virtually all forms of basal and stimulated secretion.' These data can be seen to support the common mediator hypothesis championed in the last three decades by Code2 3 and which states that secretory st...

UNLABELLED The aim of this study is to determine the affinity of six active compounds of Aegle Marmelos Correa, they are (E, R)-Marmin, skimmianine, (S)-aegeline, aurapten, zeorin, and dustanin as antihistamines in histamine H1 receptor in comparison to cetirizin, diphenhydramine and chlorpheniramine as ligands comparison. Previously, in the in vitro study marmin obviously antagonized the hista...

The diverse physiological functions of histamine are mediated through distinct histamine receptors. Mast cells are major producers of histamine, yet effects of histamine on mast cells are currently unclear. The present study shows that histamine induces chemotaxis of mouse mast cells, without affecting mast cell degranulation. Mast cell chemotaxis toward histamine could be blocked by the dual H...

A novel histamine receptor subtype, histamine H(3) receptor, mediates inhibition of peripheral autonomic neurotransmission. The present study was designed to examine vascular effects of histamine H(3) receptor by using a selective histamine H(3) receptor agonist, R-(-)-alpha methylhistamine (alpha-methylhistamine), in rat mesenteric resistance arteries. The isolated mesenteric vascular beds wer...

Histamine (10-7 to 10-4 M) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine in the same concentration range did not induce the production of IL-12 at all. The stimulatory or inhibitory effects of histamine on cytokine production were all antagonized by H2 receptor antagonists ranitidine and famoti...

In this paper we try to evaluate the effect of terfenadine, a selective H1-receptor antagonist on alcoholic beverage – induced bronchoconstriction. The size distribution proves that for each inflammatory action the hormone histamine is released in a large number and we conclude that the release of histamine makes a major contribution to alcoholic beverage – induced bronchoconstriction in asthma...

While many neurons are known to contain multiple neurotransmitters, the specific roles played by each co-transmitter within a neuron are often poorly understood. Here, we investigated the roles of the co-transmitters of the pyloric suppressor (PS) neurons, which are located in the stomatogastric nervous system (STNS) of the lobster Homarus americanus. The PS neurons are known to contain histami...