In the present study, infrared differential interference contrast videomicroscopy was used to examine the effect of histamine on N-methyl-D-aspartate-induced swelling in neostriatal neurons in a brain slice preparation. Histamine caused a concentration-dependent increase in swelling evoked by N-methyl-D-aspartate. By itself, histamine did not cause swelling. Electrical stimulation also caused N...

Hemodynamic responses to histamine were investigated in the anesthetized rabbit. Intravenous injections of histamine induced dose-dependent decreases in systemic arterial pressure that were blocked by the H1-receptor antagonist pyrilamine but not the H2 antagonist cimetidine. Injections of histamine and the H1 agonist 6-[2-(4-imidazolyl)ethylamine]- N-(4-trifuormethylphenyl)-heptanecardoxamide ...

A univalent and bioactive fluorescent derivative of histamine bound to the surface of human polymorphonuclear leukocytes; free histamine was found to compete with this derivative for binding sites. Histamine H2-receptor specificity was indicated by binding inhibition experiments using cimetidine (H2-specific) but not diphenhydramine (H1-specific). Video-intensification fluorescence microscopy w...

The possible role of histamine receptors in the hippocampal formation on the exploratory motivation and emotionality of the rat was studied. An elevated asymmetric plus-maze composed of 4 different arms (no walls, single high wall, high and low walls and two high walls) arranged at 90 degrees angles was used. The exploration score, considered to be an index of exploratory motivation, and the pe...

Changes in cyclic nucleotide production and atrial dynamics have been known to modulate atrial natriuretic peptide (ANP) release. Although cardiac atrium expresses histamine receptors and contains histamine, the role of histamine in the regulation of ANP release has to be defined. The purpose of the present study was to define the effect of histamine on the regulation of ANP release in perfused...

Modification of the cardiac rhythm by histamine has been appreciated almost since the compound's isolation from ergot by Barger and Dale in 1910. The major arrhythmogenic actions of histamine are an Hi-receptor-mediated slowing of atriovenrricular (AV) conduction and H2-receptor-mediated increases in sinus rate and ventricular automaticity. These actions were elucidated by observing the salutar...

Modification of the cardiac rhythm by histamine has been appreciated almost since the compound's isolation from ergot by Barger and Dale in 1910. The major arrhythmogenic actions of histamine are an Hi-receptor-mediated slowing of atriovenrricular (AV) conduction and H2-receptor-mediated increases in sinus rate and ventricular automaticity. These actions were elucidated by observing the salutar...

Aryl hydrocarbon receptor (AhR) is a transcription factor that plays crucial role in skin homeostasis, regeneration and barrier. Tapinarof, an agonist of AhR, was reported to improve pruritus patients with atopic dermatitis; however, the AhR regulating itch remains unknown. Therefore, we aimed investigate regulation. Pruritogens, including histamine, chloroquine, trypsin serotonin were intrader...

GABRB3 gene is a recently identified located in 15q12 chromosome and encodes for gamma-aminobutyric acid (GABA) receptor subunit beta-3 protein, which linked to the GABAA receptor. The believed share role inhibitory GABAergic synapses, GABA iron-gated channel function, possible cellular response histamine. β3 expressed cerebral grey matter, thalami, hippocampi, cerebellum, among other structure...

Histamine is a well-known mediator eliciting a broad range of responses in different cell types. Four different subtypes of G protein-coupled histamine receptors (H1-H4) have been cloned and pharmacologically characterized. However, involvement of the different histamine receptor subtypes in immunomodulatory functions of bronchial epithelium has only been investigated marginally. The expression...