Sustained release of thermal-instable and water-soluble drugs with low molecule weight is a challenge. In this study, sodium bicarbonate was encapsulated in ethyl cellulose microspheres by a novel solid-in-oil-in-oil (S/O/O) emulsification method using acetonitrile/soybean oil as new solvent pairs. Properties of the microspheres such as size, recovery rate, morphology, drug content, and drug re...

Poly (lactic-co-glycolic acid) (PLGA) coatings on implant materials are widely used in controlled drug delivery applications. Typically, such coatings are made with non-porous films. Here, we have synthesized a thin PLGA film coating with a highly ordered microporous structure using a simple and inexpensive water templating "breath figure" technique. A single stage process combining spin coatin...

Water-soluble tetraazaperopyrene (TAPP) derivatives have been synthesized, which show both high photostability and high fluorescence quantum yields (>80%) in water. Furthermore delivery of the dye into cells demonstrated selective staining of the nucleus.

BACKGROUND Human serum has the potential to become the most informative source of novel biomarkers, but its study is very difficult due to the incredible complexity of its molecular composition. We describe a novel tool based on biodegradable nanoporous nanoparticles (NPNPs) that allows the harvesting of low-molecular-weight fractions of crude human serum or other biofluids. NPNPs with a diamet...

A simple one-pot hydrothermal approach has been demonstrated for the preparation of highly water soluble and photoluminescent carbon nanodots (C-dots) from low-cost organic compounds. We found that the compounds incorporating amino and carboxylic acid groups are suitable for the preparation of highly photoluminescent and water-soluble C-dots.

Water-soluble perylene tetracarboxylic acid bisimides (PBIs) with terminally linked polyglycerol dendrons of four different generations have been synthesized. These PBI dyes reveal a strong dendritic effect, enabling outstanding fluorescence quantum yields in water up to almost 100% for the highest dendron generation.

School of Chemistry, Bio21 Institute, University of Melbourne, 30 Flemington Road, Parkville, Vic. 3010, Australia. Department of Biochemistry and Molecular Biology, Bio21 Institute, The University of Melbourne, 30 Flemington Road, Parkville, Vic. 3010, Australia. Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK. Depart...

conclusions this study demonstrated that physicochemical properties, in vitro release and rat intestine permeability were dependent upon the contents of s/c, water and oil percentage in formulations. background self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polym...

A colorimetric and fluorescent probe C-Py-1 for ONOO(-) was prepared and it could exhibit high sensitivity and excellent selectivity toward ONOO(-) among reactive oxygen species (ROS) and reactive nitrogen species (RNS) with a rapid response time in 100% water solution. Meanwhile, C-Py-1 was successfully applied in the imaging of endogenous ONOO(-) in RAW264.7 cells.