conclusions according to the liver microrna data of chinese tree shrew, characteristics of the mir-122 and let-7 families further highlight the suitability of tree shrew as the animal model in hcv research. objectives this study aimed to construct a liver microrna (mirna) data of the tree shrew. materials and methods three second filial generation tree shrews were used in this study. total rna ...

conclusions by applying wes, both novel and known scz pathogenic variants with complete or incomplete segregation in the families with multiple cases of schizophrenic patients were identified. background schizophrenia (scz) is a complex neuropsychiatric disorder characterized by pronounced genetic heterogeneity. much of the genetic architecture of the disorder has not yet been clearly elucidate...

Grid Computing allows coordinated and controlled resource sharing and problem solving in multi-institutional, dynamic virtual organizations. Moreover, fault tolerance and task scheduling is an important issue for large scale computational grid because of its unreliable nature of grid resources. Commonly exploited techniques to realize fault tolerance is periodic Checkpointing that periodically ...

expert discovery is a quest in search of finding an answer to a question: “who is the best expert of a specific subject in a particular domain within peculiar array of parameters?” expert with domain knowledge in any field is crucial for consulting in industry, academia and scientific community. aim of this study is to address the issues for expert-finding task in real-world community. collabor...

MOTIVATION In high-throughput screens (HTS) of small molecules for activity in an in vitro assay, it is common to search for active scaffolds, with at least one example successfully confirmed as an active. The number of active scaffolds better reflects the success of the screen than the number of active molecules. Many existing algorithms for deciding which hits should be sent for confirmatory ...

DNA-based taxonomic and functional profiling is widely used for the characterization of organismal communities across a rapidly increasing array of research areas that include the role of microbiomes in health and disease, biomonitoring, and estimation of both microbial and metazoan species richness. Two principal approaches are currently used to assign taxonomy to DNA sequences: DNA metabarcod...

In previous work we have shown how (max,+)-algebra can be used to model cyclically operated high-throughput screening systems. In this paper the system is modeled in a two-dimensional dioid M ax in [[γ, δ]]. A controller is determined using residuation theory. The resulting control guarantees just-in-time operation of the plant. A small example is used to demonstrate the approach to model and c...

High-throughput screening (HTS) using model organisms is a promising method to identify a small number of genes or drugs potentially relevant to human biology or disease. In HTS experiments, robots and computers do a significant portion of the experimental work. However, one remaining major bottleneck is the manual analysis of experimental results, which is commonly in the form of microscopy im...