AIM To elucidate the optical basis for unilateral high myopia and to identify the factors associated with its development. METHODS Medical records of 48 children (aged 4 months to 17 years; mean age 6.8 years) with unilateral high myopia (5 dioptres or more) seen consecutively by the author during a 15 year period were reviewed. 45 (94%) of the 48 patients had unilateral axial myopia. RESUL...

PURPOSE To assess prevalence and associated factors of myopia and high myopia in schoolchildren in Greater Beijing. METHODS The school-based, cross-sectional Greater Beijing School Children Myopia study was carried out in the year 2016 in 54 schools randomly selected from 15 districts in Beijing. Non-cycloplegic auto-refractometry of the right eyes was performed. RESULTS The study included ...

PURPOSE To determine the prevalence and associations of myopia in schoolchildren in provincial Western China. METHODS In the school-based observational cross-sectional Gobi Desert Children Eye Study, cylcoplegic refractometry as part of a comprehensive ophthalmic examination was performed in all schools in the oasis region of Ejina. Out of 1911 eligible children, 1565 (81.9%) children with a ...

The association between myopia and high intelligence has been the subject of much vexed debate in academic circles, particularly over the last two decades. This debate has risen from the observation that, over recent centuries, the prevalence of myopia amongst most populations has coincided with a marked increase in the average level of intelligence in these populations. The relationship betwee...

PURPOSE The aim is to evaluate the association between high myopia and genetic variant in the BicC family RNA binding protein 1 (BICC1) as well as its association with Ras protein specific guanine nucleotide releasing factor 1 (RASGRF1) genes in a Chinese Han population with a case-control study. METHODS Five TagSNPs in BICC1 and RASGRF1 genes were selected and genotyped in 821 unrelated subj...

Association studies have revealed that the rs1635529 polymorphism in the COL2A1 (collagen, type Ⅱ, α 1) gene may be a potential candidate for myopia development and may be associated with myopia in Caucasians. The aim of this study was to investigate the association of high myopia with 5 polymorphisms including rs1635529 in COL2A1 in a Chinese population. Genomic DNA samples were selected from ...

PURPOSE. To investigate the relationship between high myopia and single nucleotide polymorphisms (SNPs) in six proteoglycan genes: aggrecan (ACAN), fibromodulin (FMOD), decorin (DCN), lumican (LUM), keratocan (KERA), and epiphycan (EPYC). These genes were selected for study because they are involved in induced myopia in animals and/or are within the human MYP3 locus identified by linkage analys...

PURPOSE Few population-based data support the hypothesis that refractive errors are associated with depressive symptoms. We aim to assess the impact of myopia on the risk of having depressive symptoms in a community-based cohort of elderly Chinese. METHODS A community-based cross-sectional study of 4611 Chinese adults aged 60 years or older was conducted. Depressive symptoms were measured usi...

High myopia is a global eye health problem because of its high incidence of sight-threatening complications. Due to the role of awareness, self-examination, and preventive behavior in prevention of morbidity of high myopia complications, promoting knowledge, capabilities, and attitude of high myopic personnel are required in this regard.In this quasi-experiment study, 31 freshmen with high myop...

PURPOSE Myopia is a common, complex disorder, and severe forms have implications for blindness due to increased risk of premature cataracts, glaucoma, retinal detachment, and macular degeneration. Autosomal dominant (AD) non-syndromic high-grade myopia has been mapped to chromosomes 18p11.31, 12q21-23, 17q21-23, 7q36, 2q37.1, 7p15.3, 15q12-13, 3q26, 4q12, 8p23, 4q22-q27, 1p36, and Xq23-q25. Her...