نتایج جستجو برای: high grade glioma
تعداد نتایج: 2202508 فیلتر نتایج به سال:
BACKGROUND Due to their invasive growth, gliomas usually cannot be removed completely and almost always recur as same grade or higher grade malignancies. OBJECTIVE To determine whether there were differences in the accumulation of genetic changes between the two types of glioma recurrence. METHODS We genetically characterised 14 cases of lower grade glioma with a same grade recurrence, 12 c...
OBJECTIVE To assess the feasibility of synthesis of O-(2-[(18)F]-fluoroethyl)-l-tyrosine (FET), a new positron emission tomographic (PET) tracer described in several studies but not yet considered standard in management of glioma, in routine practice and to determine FET uptake in a homogeneous group of patients with suspected high-grade glioma. DESIGN Prospective nonrandomized trial. PATIE...
Here, we report that microRNA-584-3p (miR-584-3p) is up-regulated in hypoxic glioma cells and in high-grade human glioma tumors (WHO grades III-IV) relative to normoxic cells and to low-grade tumors (WHO grades I-II), respectively. The postoperative survival time was significantly prolonged in the high-grade glioma patients with high miR-584-3p expression compared with those with low miR-584-3p...
High-grade gliomas are devastating brain tumors associated with a mean survival of <50 weeks. Two of the most common genetic changes observed in these tumors are overexpression/ mutation of the epidermal growth factor receptor (EGFR) vIII and loss of PTEN/MMAC1 expression. To determine whether somatically acquired EGFRvIII expression or Pten loss accelerates high-grade glioma development, we us...
BACKGROUND AND PURPOSE Sensitivity, positive predictive value (PPV), and negative predictive value (NPV) of conventional MR imaging in predicting glioma grade are not high. Relative cerebral blood volume (rCBV) measurements derived from perfusion MR imaging and metabolite ratios from proton MR spectroscopy are useful in predicting glioma grade. We evaluated the sensitivity, specificity, PPV, an...
Glioma, especially the high-grade glioma, is the most common primary brain malignant tumor, with extremely poor prognosis. Angiogenesis has been demonstrated to play a crucial role in the growth and metastasis of glioma. Fibulin-5 is a multifunctional extracellular matrix (ECM) protein that mediates cell-cell and cell-matrix communication. Recent evidence has suggested that Fibulin-5 is involve...
The clinical value of MR diffusion tensor imaging (DTI) in grade diagnosis of gliomas was investigated. A total of 31 patients with glioma were administered 3.0T MR convention and DTI examination, with quantitative measurement of anisotropy coefficient fractional anisotropy (FA) and apparent dispersion coefficient (ADC) value, and the comparison of quantitative parameters of glioma between low-...
Glioblastoma (GBM) is a high-grade glioma with a complex microenvironment, including various inflammatory cells and mast cells (MCs) as one of them. Previously we had identified glioma grade-dependent MC recruitment. In the present study we investigated the role of plasminogen activator inhibitor 1 (PAI-1) in MC recruitment.PAI-1, a primary regulator in the fibrinolytic cascade is capable of fo...
BACKGROUND To assess gliomas using image-based estimation of cellularity, we utilized isotropic diffusion spectrum imaging (IDSI) on clinically feasible diffusion tensor imaging (DTI) and compared it with amino acid uptake measured by α[(11)C]methyl-L-tryptophan positron emission tomography (AMT-PET). METHODS In 10 patients with a newly-diagnosed glioma, metabolically active tumor regions wer...
The co-occurrence of a vestibular schwannoma and a low-grade glioma is rare, and even rarer is the association with an oligodendroglioma. Although various authors have addressed the problem of treating patients with incidentally discovered indolent low-grade gliomas, an established protocol does not exist to date. The common approach is to reserve surgery until there is radiological evidence of...
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