High-Intensity Focused Ultrasound (HIFU) is an emerging non-invasive surgical technique. HIFU systems are generally designed to deliver a fixed amount of energy to tissue, but because the tissue thermal response is variable across patients and tissue type, this approach can often lead to underdosing or overdosing. In order to improve the dosing precision in HIFU we are investigating real time m...

Current HIFU challenges include amount of tissue that can be destroyed by a single exposure, the inability to treat through bone, difficulty in monitoring therapy in real‐time, and difficulty in planning the strategy before therapy. Technological advances such as multi‐transducer or array beam generator, instrumentation and image‐based guidance of HIFU treatment promise to overcome many of thes...

Pancreatic cancer is under high mortality but has few effective treatment modalities. High-intensity focused ultrasound (HIFU) is becoming an emerging approach of noninvasively ablating solid tumor in clinics. A variety of solid tumors have been tried on thousands of patients in the last fifteen years with great success. The principle, mechanism, and clinical outcome of HIFU were introduced fir...

Attractivity of robotic high intensity focused ultrasound (HIFU) is based largely on the non-invasive, extremely precise nature of this high-tech robotic therapy as well as its clean, radiation free, surgical, but nevertheless, bloodless character. Today, in urological oncology, HIFU is used clinically as a therapeutic tool for the treatment of prostate cancer. Experimentally it is investigated...

Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of High-Intensity Focused Ultrasound (HIFU) surgery. However, accurate localization and characterization of the effective region of treatment (thermal lesion) remain the obstacles in the clinical implementation of HIFU ablation. Harmonic motion imaging for focused ultrasound (HMIFU) is a novel HIFU ...

PURPOSE To evaluate therapeutic efficacy of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) ablation for treatment of needle-track seeding of hepatocellular carcinoma (HCC). MATERIALS AND METHODS Nine patients with needle-track seeding of HCC were treated as outpatients using US-guided HIFU ablation. The mean size of the lesion was 1.8 cm (range 1.1 to 2.6 cm), two lesions wer...

This work describes the development of a non-invasive real-time technique to detect changes in tissue caused by the production of multiple lesions during a HIFU treatment sequence. It is based on estimation of relative changes in tissue properties derived from backscattered RF data, such as speed of sound, density, absorption coefficient, backscattering power, etc., as a function of HIFU exposu...

BACKGROUND High-intensity focused ultrasound (HIFU) allows to inflict intracorporal thermal lesions without penetrating the skin or damaging the surrounding tissue. This analysis intends to assess the magnitude of HIFU-induced ablations within benign thyroid nodules using scintigraphic imaging with (99m)Tc. METHODS Ten cold, hot, or indifferent nodules were treated using multiple pulses of HI...

BACKGROUND Left atrial-esophageal fistula is a serious and poorly understood complication of catheter ablation of atrial fibrillation. The purpose of this study was to (1) develop a canine model of esophageal injury and left atrial-esophageal fistula after applications of forward-firing high-intensity focused ultrasound (HIFU) and side-firing unfocused ultrasound (SFU); (2) examine the relation...