OBJECTIVE To understand how the concept of Health Information Exchange (HIE) has evolved over time. METHODS  Supplementary analysis of data from a systematic scoping review of definitions of HIE from 1900 to 2014, involving temporal analysis of underpinning themes. RESULTS The search identified 268 unique definitions of HIE dating from 1957 onwards; 103 in scientific databases and 165 in Go...

Although studies of infective lung diseases have demonstrated that Haemophilus influenzae is a major pathogen, the mechanisms underlying pathogenesis by this organism are not clear. We have cultured human bronchial epithelial cells (HBEC) to confluency and have investigated the effect of H. influenzae endotoxin (HIE) on: 1) epithelial permeability, by movement of 14C-bovine serum albumin (14C-B...

Treatments for neonatal hypoxic-ischemic encephalopathy (HIE) have been limited. The aim of this paper is to offer translational research guidance on stem cell therapy for neonatal HIE by examining clinically relevant animal models, practical stem cell sources, safety and efficacy of endpoint assays, as well as a general understanding of modes of action of this cellular therapy. In order to do ...

OBJECTIVE Relevant patient information is frequently difficult to obtain in emergency department (ED) visits. Improved provider access to previously inaccessible patient information may improve the quality of care and reduce hospital admissions. Health information exchange (HIE) systems enable access to longitudinal, community-wide patient information at the point of care. However, the ability ...

OBJECTIVE We examined two potential biomarkers of brain damage in hypoxic-ischemic encephalopathy (HIE) neonates: glial fibrillary acidic protein (GFAP; a marker of gliosis) and ubiquitin C-terminal hydrolase L1 (UCH-L1; a marker of neuronal injury). We hypothesized that the biomarkers would be measurable in cord blood of healthy neonates and could serve as a normative reference for brain injur...

OBJECTIVE To establish an early diagnostic system for hypoxic ischemic encephalopathy (HIE) in newborns based on artificial neural networks and to determine its feasibility. METHODS Based on published research as well as preliminary studies in our laboratory, multiple noninvasive indicators with high sensitivity and specificity were selected for the early diagnosis of HIE and employed in the ...

Abstract. Health Information Exchange (HIE) can have several benefits, in particular facilitating access to and sharing of patient-related information. Despite these potential benefits, implementation and maintenance of HIEs have been challenging and many attempts to develop HIEs have been abandoned. Most research on HIE focuses on the financial, organizational, and technical aspects of HIE and...

BACKGROUND Much attention has been given to the proposition that the exchange of health information as an act, and health information exchange (HIE), as an entity, are critical components of a framework for health care change, yet little has been studied to understand the value proposition of implementing HIE with a statewide HIE. Such an organization facilitates the exchange of health informat...

BACKGROUND The ability to sustain brief high-intensity intermittent efforts (HIE) is meant to be a major attribute for performance in team sports. Adding changes of direction to HIE is believed to increase the specificity of training drills with respect to game demands. The aim of this study was to investigate the influence of 90°-changes of direction (COD) during HIE on metabolic and neuromusc...

BACKGROUND Infantile and undifferentiated immune cells in the pathogenesis of neonates with HIE have been studied in recent years. This study was undertaken to observe the expression level of T subsets and membrane interleukin-2 receptor (mIL-2R) in the peripheral blood of newborns with hypoxic ischemic encephalopathy (HIE) and its clinical manifestations. METHODS The peripheral blood mononuc...