DNA sequences corresponding to a novel herpesvirus (human herpesvirus 8 [HHV8]) are associated with Kaposi's sarcoma (KS), Castleman's disease, and body cavity-based lymphomas (BCBL). Studies of a BCBL-derived cell line suggest a direct correlation between seropositivity against antigens specifically present in such lines and the development of KS. We have generated recombinant proteins corresp...

The evidence that Kaposi’s sarcoma (KS)-associated herpesvirus (also known as human herpesvirus 8 [HHV8]) is the primary etiologic agent of KS in both acquired immunodeficiency syndrome (AIDS) and non-AIDS situations has been accumulating rapidly. Two recent articles, one by Dupin et al. (1) and the other by Sturzl et al. (2), which appears in this issue of the Journal, provide the most compell...

BACKGROUND The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions. CASE PRESENTATION We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing ...

Introduction: Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin’s lymphoma, which is characterized by serous effusion in body cavities without detectable tumor masses or lymphadenopathy. It is usually found in human herpes virus 8 (HHV8) and human immunodeficiency virus (HIV) positive patients, and tumor cells usually show a B-cell–lineage immunophenotype. Case presentation: In the ...

Expression profiling of cellular genes was performed using a 10,000 cDNA human gene array in order to identify expression changes following chronic infection of human hematopoietic cells with Kaposi's Sarcoma-associated Virus (KSHV) also known as Human Herpesvirus 8 (HHV8) and Human T cell leukemia virus-1 (HTLV-1). We performed cell-free in vitro infection of primary bone marrow derived CD34+ ...