نتایج جستجو برای: hexamethonium
تعداد نتایج: 1139 فیلتر نتایج به سال:
Probably the first studies of the pharmacology of quaternary ammonium compounds were made by Crum-Brown and Fraser in 1868. Burn and Dale (1915) found that, unlike nicotine, tetraethyl-ammonium chloride blocked autonomic ganglia without noticeable initial stimulation. Barlow and Ing (1948a and b), Paton and Zaimis (1948a and b), and Balaban et al. (1949) studied the properties of some chemical ...
Nicotinic receptor (nAChR) subtypes involved in preand postjunctional actions underlying tetanic fade were studied in rat phrenic-nerve hemidiaphragms. We investigated the ability of subtype-specific nAChR antagonists to depress nerve-evoked contractions and [H]-acetylcholine ([H]-ACh) release. Muscle tension was transiently increased during brief high frequency trains (50 Hz for 5 sec). The ra...
Santos, Javier, Paul R. Saunders, Nico P. M. Hanssen, Ping-Chang Yang, Derrick Yates, Jack A. Groot, and Mary H. Perdue. Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G391– G399, 1999.—We examined the effect of stress on colonic epithelial physiology, the role of corticotropin-releasing...
The effects of acetylcholine and nicotine on isometric tension, in the presence and absence of atropine, hexamethonium, and endogenous norepinephrine stores, were examined in isolated cat atria and papillary muscles. Acetylcholine exerted a negative inotropic effect, competitively inhibited by atropine, in atrial and papillary muscle; in higher concentrations in papillary muscles, it produced a...
The effects of selective nicotinic acetylcholine (ACh) receptor (nAChR) agonists and antagonists on the stimulation-evoked release of [3H]ACh were studied in rat isolated superior cervical ganglion loaded with [3H]choline and superfused in a 2-ml chamber. Nicotine and 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), but not cytisine, increased the stimulation (2 Hz)-evoked release of [3H]ACh in...
The present study investigated the effects of subcutaneous (sc) and intracerebroventricular (icv) injections of physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic cholinergic receptors) on the acute corneal nociception in rats. Local application of 5 M NaCl solution on the corneal surface of the ...
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