Abstract The Omicron BA.5 subvariant of SARS-CoV-2 markedly escapes neutralizing antibodies induced by vaccination due to mutations in the Spike (S) protein. Solid organ transplant recipients (SOTRs) suffer high COVID-19 morbidity, yet show poor ancestral strain recognition after vaccination. CD8+ T cell responses may provide a crucial second line defense. Therefore, it is critical understand w...

objective: enterotoxigenic escherichia coli is considered as the most important agent of children diarrhea and mortality in developing countries. this bacterium causes 300-600 thousands of deaths in the children under 5 years of age per year. with difficulties in treatment as well as its wide prevalence, designing an effective vaccine against this microorganism is the objective of world health ...

autologous bone is considered the first choice as material of cranioplasty because of its biological and anatomical features. however in some situations such as skull fractures or tumors the bone flap is not available or it must be replaced with a heterologous cranioplasty because of the development of surgical complications. authors of this study aimed to identify which are the best materials ...

There is considerable controversy over whether μ-opioid receptor (MOPr) desensitization is homologous or heterologous and over the mechanisms underlying such desensitization. In different cell types MOPr desensitization has been reported to involve receptor phosphorylation by various kinases, including G-protein-coupled receptor kinases (GRKs), second messenger and other kinases as well as pert...

Heterologous protein production can be doubled by increasing the copy number of the corresponding heterologous gene. We constructed a host-vector system in the yeast Kluyveromyces lactis that was able to induce copy number amplification of pKD1 plasmid-based vectors upon expression of an integrated copy of the plasmid recombinase gene. We increased the production and secretion of two heterologo...

Avian infectious bronchitis virus (IBV) defective RNAs (D-RNAs) have been used for the expression of heterologous genes in a helper-virus-dependent expression system. The heterologous genes were expressed under the control of an IBV transcription-associated sequence (TAS) derived from gene 5 of IBV Beaudette. However, coronavirus D-RNA expression vectors display an inherent instability followin...

This paper describes the first physiological response at the translational level towards heterologous protein production in Saccharomyces cerevisiae. In yeast, the phosphorylation of eukaryotic initiation factor 2alpha (eIF-2alpha) by Gcn2p protein kinase mediates derepression of GCN4 mRNA translation. Gcn4p is a transcription factor initially found to be required for transcriptional induction ...

conclusions the canola oilseeds could provide a useful expression system to produce hcv core protein as a vaccine candidate. results western blot analysis using anti-his antibody confirmed the presence of a 15 kda protein in the seeds of t1 transgenic lines. the amount of antigenic protein accumulated in the seeds of these transgenic lines was up to 0.05% of the total soluble protein (tsp). mat...

The research was performed for the immunological characterization of the 37.81 kDa common immunodominant surface protein of some Salmonella serovars in order to examine the potency of that particular protein in terms of immunity production as well as withstood challenge exposure against virulent homologous and heterologous organism. The protective efficacy study in chicks gave protective levels...