Vitamin Kdependent protein S (ProS) is a plasma glycoprotein with anticoagulant properties [1]. Its anticoagulant function is well established in the literature based both in clinical data, genetics and laboratory assays. ProS is able to prolong the clotting time acting as cofactor for activated protein C. Furthermore, since the 80s it is known that hereditary ProS deficiency (PSD) increases th...

Background and objective: Thrombotic microangiopathic effects have been reported in Coronavirus Disease-2019 (COVID-19) patients. In the present study, we aimed to examine relationship between hereditary thrombophilia factors clinical picture severity of COVID-19 Methods: Ninety patients were included grouped according three groups: severe/critical (n=30), mild/moderate (n=30) asymptomatic (n=3...

BACKGROUND As the placental vessels are dependent on the normal balance of procoagulant and anticoagulant mechanisms, inherited thrombophilia may be associated with fetal loss. OBJECTIVES We performed a prospective study to investigate the relation between inherited thrombophilia and fetal loss, and the influence of thromboprophylaxis on pregnancy outcome. PATIENTS AND METHODS Women were en...

Pregnancy is a normal physiological state that predisposes to thrombosis, determined by hormonal changes in the body. These changes occur in the blood flow (venous stasis), changes in the vascular wall (hypotonia, endothelial lesion) and changes in the coagulation factors (increased levels of factor VII, factor VIII, factor X, von Willebrand factor) and decreased activity levels of natural anti...

Nearly 150 years ago, Virchow postulated that thrombosis was caused by changes in the flow of blood, the vessel wall, or the composition of blood. This concept created the foundation for subsequent investigation of hereditary and acquired hypercoagulable states. This review will focus on an example of the use of modern genetic epidemiologic analysis to evaluate the multigenic pathogenesis of th...

PURPOSE Hereditary thrombophilia (HT) is a major risk factor for idiopathic pulmonary embolism (iPE) and shows different prevalence among ethnic groups. The prevalence and clinical characteristics of HT in Korean patients with iPE were investigated. MATERIALS AND METHODS Patients with PE on computed tomography (CT) scan were recruited, and those with malignancy were excluded. Patients were di...

At 34 weeks gestation she went into premature labour and both twins were delivered vaginally. The first twin (male) was cephalic presentation and born with Apgar scores of 5 and 8 at 1 minute and 5 minutes respectively and weighed 2.54 kg. The second twin (female), also cephalic presentation diagnosed as an intrauterine death (IUD) and a macerated stillborn weighing 1.94 kg was delivered. Two s...

introduction: the main inhibitors of coagulation pathway are antithrombin (at), protein c and protein s. these inhibitors are necessary to prevent thromboembolism. hereditary deficiency of inhibitors is the main cause of alteration in balance between the anti-clotting and the formation of thrombin. patients with this abnormality are susceptible to venous thromboembolism (vte). two major clinica...