A WDE variety of nutritional deficiencies producing gradual loss of transparency in the human lens as well as in the lenses of laboratory animals, has been reported (Oomen, 1954; Pirie and van Heyningen, 1956). The development of lenticular opacities and finally the liquefaction of lens fibres are the visible changes among these affected animals (Passmore, 1947). Pathologically, muscular dystro...

fibrillin-rich microfibrils are susceptible to degradation by serine proteases, and the amino acid substitutions found in Marfan syndrome change the fragmentation patterns. Fibrillin degradation products generated by MMP activity provide conclusive evidence that these enzymes cause specific changes to assembled microfibrils. In Marfan syndrome, most of the mutations in fibrillin-1 are found wit...

Anterior megalophthalmos is characterized by megalocornea associated with a very broad anterior chamber and ciliary ring elongation. It is also called X-linked megalocornea. It is accompanied by early development of cataracts, zonular anomalies, and, rarely, vitreoretinal disorders. Subluxation of a cataract can occur in cataract surgery because of zonular weakness. In addition, in most patient...

A four-year-old, male German Shepherd dog with severe pain in the left eye following a corneal perforation with a foreign body was examined. An ophthalmic examination revealed conjunctival hyperaemia and pancorneal dense oedema, preventing a diagnosis of deeper structures of the eye and lowered IOP. Vision testing was missing or impossible to detect. Ultrasonography showed a solid hyperechoic l...

Visual examination, without instruments, of the eye allows inspection of the iris, sclera, cornea and, through the iris, some abnormalities of the lens and retina. Several hereditary disorders can easily be recognised by characteristic iris changes. This review discusses changes in the iris, visible lens anomalies, and changes in the cornea surrounding the iris. A genetic diagnosis can help wit...

fibrillin-rich microfibrils are susceptible to degradation by serine proteases, and the amino acid substitutions found in Marfan syndrome change the fragmentation patterns. Fibrillin degradation products generated by MMP activity provide conclusive evidence that these enzymes cause specific changes to assembled microfibrils. In Marfan syndrome, most of the mutations in fibrillin-1 are found wit...

PURPOSE The authors present a patient with Marfan syndrome who underwent cataract surgery using a novel device for fixation of capsular bag. METHODS The capsule fixation device (CFD) is poly(methyl methacrylate) arch with double-armed bent hook that can be introduced into the anterior chamber through the clear corneal incision, placed with a rest on the capsule equator, and sutured to the scl...

EHUD I. ASSIA, MD The combination of advanced glaucoma and phacodonesis with lens subluxation suggests pseudoexfoliation (PXF) syndrome, which needs to be ruled out. Another potential cause is high myopia, in which significant phacodonesis is not uncommon. Cataract extraction is certainly indicated, not only to remove the opaque media but also because of the patient’s glaucoma. Anterior displac...