Several rat and mouse hepatomas and the liver and kidneys of the host animals were assayed for catalase activity. Little or no activity could be demonstrated in the subcutaneously transplanted Novikoff hepatoma, Hepatoma LC18, and Hepatoma 3683 of rats, and in a number of transplanted hepatomas of mice and hamsters. A relatively high activity was found, however, in the transplanted Hepatoma 512...

BACKGROUND It is well known that various polysaccharides present anti-tumour effects by inducing cell apoptosis and immunomodulation. However, it is still unclear about the roles of polysaccharides isolated from Artemisia apiacea (HQG) to hepatoma and its underlying mechanism. The objective of the study was to examine the anti-hepatoma effects of HQG and its related mechanism. MATERIALS AND M...

The specificity of Fr histones from tumors was investigated with the following immunological probes: antisera elicited by each of the Fr subfractions obtained from rat thymus; antisera elicited by purified unfractionated rat hepatoma FI histones; and antisera elicited by the COOH-terminal (N1) fragment of rat hepatoma F1 histones. The results indicate that Fr histones derived from tumors retain...

For the biochemical characterization of a new transplantable hepatoma derived from the MC-29 virus-induced liver tumor, the macromolecular content and the inducibility of glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, and aryl hydrocarbon hydroxylase were compared in chicken liver and in this hepatoma. The alteration of the nucleocytoplasmic ratio was deduced from measurements of DNA...

Zajdela hepatoma cells are poorly-adherent cells derived from an undifferentiated tumour and transplanted into rat. We compared the biosynthesis, structure and function of the fibronectin receptor in normal rat hepatocytes with that in Zajdela hepatoma cells. The rat hepatocyte fibronectin receptor has been isolated. It is composed of two subunits: alpha 5 (molecular mass 155 kDa) and beta 1 (m...

rat liver and the Novikoff hepatoma have been examined by two competitive hybridization techniques and by nucleotide analyses. Significant differences were not found between the corresponding RNA of these tissues by competition of labeled RNA from the hepatoma with unlabeled 18 and 28 S ribosomal RNA and 28 and 45 S nucleolar RNA of liver and hepatoma by sequential or simultaneous competition h...

A two-dimensional polyacrylamide gel electrophoresis technique is presented for separation of acid-extracted proteins of isolated nucleoli of normal rat liver and Novikoff hepatoma ascites cells. About 100 distinct protein spots were resolved. Comparison of the patterns for normal liver and Novikoff hepatoma revealed nine spots with markedly different intensities in the two patterns. Two spots ...

Hepatocellular carcinoma is one of the most common cancers in the world. Previously, we found that the level of glucocorticoid receptor was significantly higher in hepatocellular carcinoma than in adjacent liver tissues. Moreover, in vitro and in vivo studies showed that glucocorticoid stimulated the growth of hepatoma cells. On the other hand, endogenous metabolites such as 2-methoxyestradiol,...

S-Adenosylmethionine-homocysteine methyltransferase, which catalyzes synthesis of methionine from homocysteine, with the use of S-adenosylmethionine as the methyl donor, is absent in tumor tissue such as rat ascites hepatoma and Morris hepatoma but is present in rat liver homogenate. Absence of the enzymatic activity in tumor cells is not due to the action of an inhibitor. S-Adenosylhomocystein...

Glutamine phosphoribosylpyrophosphate amidotransfer ase (amidophosphoribosyltransferase, EC 2.4.2.1 4) from normal rat liver and rapidly growing Morris hepatoma 3924A has been purified 1622-and 1224-fold, respectively. Acryl amide gel electrophoresis demonstrated that the purified amidotransferase from liver and hepatoma had the same mobility. Kinetic studies established that the purified en zy...