conclusions the results of this study indicate that the rs12979860 cc genotype of il28b was associated with a response to peg-ifnα-2a/rbv combination therapy in azerbaijani patients with hcv-1b infection. therefore, host genetics may be useful in predicting the response to hepatitis c treatment. objectives the aim of the current study was to determine the relationship between rs12979860 polymor...

background hepatitis c virus (hcv) infection still exists as a health concern among the transplant patients. because of the severity of the disease, different responses to treatment, and side effects resulting from long therapeutic period, determination of genotypes and viral loads can help choose the best treatment protocols. objectives this study aimed to determine the hcv genotypes and its d...

background hepatitis c virus (hcv) infection is one the major health concern among the infected transplant patients. considering several complications of the disease in them, pre and post-transplantation studies should be performed for monitoring of the infection, as well as, developing new treatment protocols. objectives the current study was conducted to determine the hepatitis c virus rna le...

objectives in the current case control study, we aimed to compare the histopathological findings of liver to the ccr5δ32 bpdel mutation profiles, expression and some other clinical findings in patients with chronic hcv infection. background the specific antiviral t cells provide cc chemokine receptor 5 (ccr5) for the immune response during the hepatitis c virus (hcv) infection. heterogenous and...

Influenza C virus possesses specific neuraminate-O-acetylesterase as a receptor-destroying function. This enzymatic activity of the viral glycoprotein HEF (Hemagglutinin, esterase activity and fusion factor) can be visualized in situ by the use of distinct color substrates. Hereby the localization, as well as the quantity of synthesized HEF protein is detectable. We further developed the estera...

background and aims: natural killer t (nkt) cells have been suggested to play critical roles in a wide range of immune responses especially against hepatotropic pathogens such as hepatitis c virus (hcv). in  the  present  study,  we  investigated  the  status  of  nkt  cells  by producing interleukin-17 cytokine in  peripheral  blood.  patients and methods: as case-control study, 15 patients wi...

results the predominant genotype among bahraini patients was type 1 (36.71%), followed by genotypes 3 and 4 (15.6% each) and the lowest frequency was found for genotype 2 (3.9%). among genotype 1, subtype 1b had the highest frequency (21.09%), followed by subtype 1a (14.06%). among genotype 3, subtype 3a had the highest frequency (11.72%), while among genotype 4, most of subtypes were undetermi...

hepatitis c virus (hcv) is a major global health problem and one of the most common causes of chronic liver diseases. the current study was carried out to investigate the ability of high resolution melting (hrm) method in hcv genotyping. 40 hcv-positive sera with unknown and 12 sera with known hcv genotypes were collected from different clinical laboratories in tehran as well as rasht in north ...

background: the aim of this study was to evaluate the effectiveness of monotherapy with interferon alpha-2b and combination therapy with interferon alpha-2b plus ribavirin on chronic hepatitis c infection in thalassaemic patients. methods: in parallel group randomized, double blind, controlled trial, 32 thalassaemic patients with chronic hepatitis c infection completed the study. in a random fa...

conclusions the results of this study revealed the important role injection drug use plays as the main cause of hcv spread in isfahan province. effective harm reduction programs should be implemented to prevent new hcv infections. considering the high prevalence of hcv infection among hiv patients, this group should receive special attention. results twenty-eight studies, including 6, 17, 4, an...