Increased hepatic lipid content is associated with hepatic as well as whole-body insulin resistance and is typical for individuals with type 2 diabetes mellitus. However, whether insulin resistance causes hepatic steatosis or whether hepatic steatosis per se reduces insulin sensitivity remains unclear. Multiple metabolic pathways lead to the development of hepatic steatosis, including enhanced ...

background: alcoholic mothers who consume ethanol give birth to infants with high percentage of hepatic diseases. alcohol can cause cellular damage in different tissues, including liver. finding a drug which is effective and efficient in reducing ethanol misuse consequences during pregnancy can assist the decrease of harmful effects of this habit. objective: this research aims to study the effe...

This study was made to determine the nature of tissue contributions to murine hepatic morphogenesis, the developmental potential in vitro of various hepatic regions prior to and during definitive liver development, and to accurately determine the time of onset of hepatic haematopoiesis in vitro. Embryos were precisely staged by somite counts as well as time of original mating, and tissues were ...

Zinc (Zn) is an essential, common metal in animal tissues. Zn levels were elevated in only four tissues after Zn administration, the highest increase being in the pancreas. Zn concentration was increased by metallothionein induction. Metallothionein-bound Zn significantly reduced the toxicity of the metals Cd, Cu and Hg. It should be noted that tissue Zn levels are different in experimental ani...

BACKGROUND: Diabetes mellitus is a chronic metabolic disorder, affected by fructose, and artificial sweeteners. Aspartame fructose are popularly used, diabetics, as substitutes to glucose. AIM: This study evaluated the effect of high aspartame on vascular reactivity, glucose, hepatic metabolism in diabetic rats. MATERIALS AND METHODS: Forty-eight male rats were divided into six groups: Control,...

Nephrotoxicity and hepatotoxicity are frequently seen adverse effects during cisplatin chemotherapy. In this study, we investigated the of agomelatine on cisplatin-induced toxicity in kidney liver. Animals were administered with a single dose (7 mg/kg, i.p.) treated (20 40 p.o) for seven days. Renal hepatic functions evaluated by measuring concentrations creatinine, BUN, AST ALT serum. Oxidativ...

COVID-19 and long vulnerabilities may be caused indirectly by albumin binding deficiency (ABD), which can corrected the correct administration of human serum (HSA). The liver is primary site nutrient regulation fluid volume maintenance; control both changes to concentration. In healthy subjects, HSA lymphatic pump (HSALNP) ensures continual pumping nutrients from that are appropriately distribu...

Insulin resistance is a hallmark of type 2 diabetes, and many insights into the functions of insulin have been gained through the study of mice lacking the IR. To gain a better understanding of the role of insulin action in the brain versus peripheral tissues, we created 2 mouse models with inducible IR inactivation, 1 in all tissues including brain (IRDeltawb), and 1 restricted to peripheral t...

The nuclear factor-κB (NF-κB) signaling pathway plays a critical role in a multitude of cellular processes. Activation of the NF-κB transcription factor family is essential for the initiation of inflammation, immunity, cell proliferation and apoptosis through a list of responsive genes. In hepatic tissue, activation of the NF-κB pathway has been implicated in a number of pathological conditions...