hepatic calcification is usually associated with infectious, vascular, or neoplastic processes in the liver. we report the first case of beta-thalassemia major with isolated diffuse hepatic calcification in a 23 year old woman, who had been transfusion-dependent since the age of 6 months. she was referred to our center with a chief complaint of abdominal pain. computed tomography scan of the ab...

Background Carvedilol is used in the management of hypertension, ischemic heart disease, heart failure and most recently, portal hypertension. It has been associated with improved outcomes regarding variceal bleeding, hepatic decompensation and death when compared to propranolol and endoscopic band ligation. The main cause of portal hypertension is cirrhosis and therefore carvedilol is increasi...

Interest has been revived in the aetiology of hepatic fibrosis in infants by the recent communications of Stokes, Berk, Malamut, Drake, Barondess, Bashe, Wolman, Farquhar, Bevan, Drummond, Maycock, Capps and Bennett (1954) and Dible, Hunt, Pugh, Steingold and Wood (1954). Dible et al. showed that hepatitis can occur during intra-uterine life with fatal results in the neonatal period, or perhaps...

Quantitative determinations of collagen were carried out on rat livers showing cirrhosis due to p-dimethylaminoazobenzene and carbon tetrachloride. A twofold increase in collagen content occurred in cirrhosis due to p-dimethylaminoazobenzene. The average total hepatic collagen as well as the per cent collagen content were doubled. The collagen content after 1(1/2) months of normal diet had fall...

Introduction Cirrhosis is the 12th leading cause of death in the United States, accounting for almost 30 thousand deaths per year (Starr 2011). !e leading causes of cirrhosis include chronic alcohol abuse and viral hepatitis; however cirrhosis is the common end pathway of several types of liver injury, including non-alcoholic fatty liver disease (NAFLD), autoimmune hepatic or biliary disease, a...

INTRODUCTION Primary biliary cirrhosis is an autoimmune disease that tends to progress to fibrosis and cirrhosis with hepatic failure. Primary biliary cirrhosis is often associated with other non- hepatic autoimmune diseases. An association with rheumatoid arthritis has been suggested to coexist in 1.8% to 5.6% of patients with primary biliary cirrhosis, but data supporting this association are...

background: intrapulmonary vascular abnormalities associated with liver cirrhosis may result in intrapulmonary right-to-left shunt and hypoxemia. the aim of this study was to use contrast enhanced echocardiography to detect intrapulmonary vascular abnormalities in patients with liver cirrhosis candidates for liver transplantation.   methods: one hundred and two adult patients underwent contrast...

BACKGROUND Hemochromatosis in white subjects is mostly due to homozygosity for the common C282Y substitution in HFE. Although clinical symptoms are preventable by early detection of the genetic predisposition and prophylactic treatment, population screening is not currently advocated because of the discrepancy between the common mutation prevalence and apparently lower frequency of clinical dis...

The purpose of the present study was to characterize uncommon portosystemic collateral circulation in hepatic cirrhosis. Portosystemic uncommon collateral circulation (UCC) was detected, characterized and evaluated by a combination of spiral computed tomography angiography, three-dimensional imaging angiography and electronic gastroscopy in patients diagnosed with hepatic cirrhosis. In total, 1...

Using hepatic vein catheterization, fractional clearance (K) and hepatic extraction rate (ER) of Indocyanine Green (ICG) and radioisotope particles (RI) were studied in cirrhotic portal hypertension (24 postnecrotic cirrhotics and 25 alcoholic cirrhotics). ICG given intravenously is cleared from blood only by hepatocytes, whereas RI are uptaken by intrahepatic (Kupffer cells) and extrahepatic r...