primary hepatic lymphoma (phl) was a rare malignancy usually presenting with abdominal pain, malaise, hepatomegaly, b-symptoms, fatigue, nausea, vomiting and jaundice. it mostly involves liver without any palpable lymphadenopathy and leukemia in peripheral blood smear. on july 22, 2014, a 64 year old man presented with abdominal pain localizing in right upper quadrant and fullness from 2 years ...

a 34-year-old hiv positive-man was admitted to the hospital due to fever and abdominal pain. constant and generalized abdominal pain started 3 months prior to admission (pta) in upper quadrants of abdomen followed by mild odynophagia, early satiety and more than 20 kg weight loss since then. intermittent fever begun 7 days pta and cough, sputum and dyspnea started since 5 days pta. his general ...

samples of formalin fixed gastrointestinal organs of three month ostrich chicks were submitted to the department of pathology, razi vaccine and serum research institute. histologically hepatitis and pancreatitis with large eosinophilic intra nuclear inclusion bodies were prominent in hepatic and pancreatic cells. these inclusions were suspected as adenovirus inclusion body hepatitis (ibh) in va...

Hepatic stellate cells are liver-resident cells of star-like morphology and are located in the space of Disse between liver sinusoidal endothelial cells and hepatocytes(1,2). Stellate cells are derived from bone marrow precursors and store up to 80% of the total body vitamin A(1, 2). Upon activation, stellate cells differentiate into myofibroblasts to produce extracellular matrix, thus contribu...

Physiologically, four major types of hepatic cells - the liver sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, and hepatocytes - reside inside liver sinusoids and interact with flowing peripheral cells under blood flow. It is hard to mimic an in vivo liver sinusoid due to its complex multiple cell-cell interactions, spatiotemporal construction, and mechanical microenvironme...

Background and aims: Activation of Kupffer cells recruitment monocytes are key events in fibrogenesis. These release soluble mediators which induce the activation hepatic stellate (HSC), main fibrogenic cell type within liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes macrophages has been implicated pathogenesis NASH-related fibrosis. In this study, we explored if MerTK...

Objective(s): Gallic acid (GA) is a highly effective antioxidant, which its beneficial effects are well known, but its impact on expression of microRNAs (miRs) following hepatic ischemia-reperfusion (I/R) is not well recognized. Therefore, the current research was designed to specify the beneficial effect of GA on miRs (122 and 34a), liver functional tests, and histopathological alterations bey...