نتایج جستجو برای: heparan sulfate

تعداد نتایج: 59167  

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2001
H B Nader M A Pinhal E C Baú R A Castro G F Medeiros S F Chavante E L Leite E S Trindade S K Shinjo H A Rocha I L Tersariol A Mendes C P Dietrich

The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfat...

Journal: :Cold Spring Harbor perspectives in biology 2011
Stephane Sarrazin William C Lamanna Jeffrey D Esko

Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and core...

Journal: :The Journal of biological chemistry 2002
Kan Ding Katrin Mani Fang Cheng Mattias Belting Lars-Ake Fransson

Cell surface heparan sulfate proteoglycans facilitate uptake of growth-promoting polyamines (Belting, M., Borsig, L., Fuster, M. M., Brown, J. R., Persson, L., Fransson, L.-A., and Esko, J. D. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 371-376). Increased polyamine uptake correlates with an increased number of positively charged N-unsubstituted glucosamine units in the otherwise polyanionic hep...

Journal: :Journal of immunology 2000
Y Kodaira S K Nair L E Wrenshall E Gilboa J L Platt

Primary immune responses are thought to be induced by dendritic cells. To promote such responses, dendritic cells must be activated by exogenous agonists, such as LPS, or by products of activated leukocytes, such as TNF-alpha and IL-1. How dendritic cells might be activated in the absence of exogenous stimuli, or without the immediate presence of activated leukocytes, as might occur in immunity...

Journal: :Development 1999
X Lin E M Buff N Perrimon A M Michelson

The Drosophila sugarless and sulfateless genes encode enzymes required for the biosynthesis of heparan sulfate glycosaminoglycans. Biochemical studies have shown that heparan sulfate glycosaminoglycans are involved in signaling by fibroblast growth factor receptors, but evidence for such a requirement in an intact organism has not been available. We now demonstrate that sugarless and sulfateles...

Journal: :Development 2005
Xianjun Zhu Jonaki Sen Leslie Stevens Jason S Goltz David Stein

The Drosophila pipe gene encodes ten related proteins that exhibit amino acid sequence similarity to vertebrate heparan sulfate 2-O-sulfotransferase. One of the Pipe isoforms, which is expressed in the ventral follicular epithelium, is a key determinant of embryonic dorsoventral polarity, suggesting that Pipe-mediated sulfation of a heparan sulfate proteoglycan provides a spatial cue for dorsov...

Journal: :Molecules 2017
Ha Na Kim John M Whitelock Megan S Lord

Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine. This study explored the effect of different bioreactor conditions on the production of heparin/heparan sulfate chains via the recombinant expression of serglycin in mammalian cells. Tissue culture flasks and continuously-stirred tank reac...

2015
Anurag Purushothaman Shyam Kumar Bandari Jian Liu James A. Mobley Elizabeth E. Brown Ralph D. Sanderson

Exosomes regulate cell behavior by binding to and delivering their cargo to target cells, however the mechanisms mediating exosomecell interactions are poorly understood. Heparan sulfates on target cell surfaces can act as receptors for exosome uptake, but the ligand for heparan sulfate on exosomes has not been identified. Using exosomes isolated from myeloma cell lines and from myeloma patient...

Journal: :Fly 2008
Youmie Park Zhenqing Zhang Robert J Linhardt Ellen K LeMosy

Spatial information embedded in the extracellular matrix establishes the dorsoventral polarity of the Drosophila embryo through the ventral activity of a serine protease cascade. Pipe is a Golgi-localized protein responsible for generating this spatial information during oogenesis through sulfation of unknown glycans. Although Pipe has sequence homology to glycosaminoglycan 2-O-sulfotransferase...

Journal: :The Journal of biological chemistry 2016
Anurag Purushothaman Shyam Kumar Bandari Jian Liu James A Mobley Elizabeth E Brown Ralph D Sanderson

Exosomes regulate cell behavior by binding to and delivering their cargo to target cells; however, the mechanisms mediating exosome-cell interactions are poorly understood. Heparan sulfates on target cell surfaces can act as receptors for exosome uptake, but the ligand for heparan sulfate on exosomes has not been identified. Using exosomes isolated from myeloma cell lines and from myeloma patie...

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