BACKGROUND There is limited evidence regarding the relationship between serum tocopherol levels and cardiovascular disease. METHODS We conducted a nested case-control study as part of the Japan Collaborative Cohort Study for evaluation of cancer risk (JACC Study). Baseline serum samples were collected from 39 242 participants (age range, 40-79 years) between 1988 and 1990. During the 13-year ...

Background and Purpose—Ischemic stroke accounts for 70% to 80% of all strokes, but intracerebral and subarachnoid hemorrhagic strokes have greater fatality. Age-standardized death rates from overall stroke are higher among men than women, but little is known about sex differences in stroke subtype mortality by race/ethnicity. Methods—We analyzed 1995 to 1998 national death certificate data to c...

Strokes in children and adults with sickle cell disease (SCD) continue to be a major cause of morbidity. Understanding the epidemiology of overt strokes is critical to the multidisciplinary, and timely acute and long-term management of strokes. The first neurologic complication associated with SCD was described in a child with sickle cell anemia (SCA), seizures, and acute left hemiparesis in 19...

BACKGROUND AND PURPOSE We sought to examine risk factors for all strokes and for ischemic stroke and primary intracerebral hemorrhage separately. METHODS This was a population-based case-control study. Each case subject meeting World Health Organization criteria for stroke (n = 536) from a population-based register of acute cerebrovascular events compiled in Perth, Western Australia, in 1989 ...

With the advances in magnetic resonance imaging, previously unrecognized small brain lesions, which are mostly asymptomatic, have been increasingly detected. Diffusion-weighted imaging can identify small ischemic strokes, while gradient echo T2* imaging and susceptibility-weighted imaging can reveal tiny hemorrhagic strokes (microbleeds). In this article, we review silent brain lesions appearin...

THE DRAMATIC DECLINE IN STROKE incidence in North America (approximately 60% in the past 15 years) has provoked much debate about the reasons for the decline. The role of the treatment of blood pressure in the reduction of stroke in general, and intracerebral hemorrhage in particular, has been a focus of the debate. Our recent experience highlights the need to pay attention, in future, to those...

BACKGROUND AND PURPOSE We evaluated a mechanical thrombectomy protocol to treat acute stroke and report the angiographic results and clinical outcomes. METHODS Patients with anterior circulation strokes <8 hours and posterior circulation strokes <12 hours were treated at a single center over 10 months. Patients were excluded if they were candidates for intravenous tissue plasminogen activator...

Stroke is the second most common cause of death and a major cause of serious long-term disability in adults in industrialized countries. Approximately 90% of strokes are ischemic and the rest are hemorrhagic.[1] Unfortunately, few effective treatments can be offered during the acute and subacute phases. Since the introduction of tissue plasminogen activator (tPA) in 1995, there are no other med...