1. A chemically pure hemolysin-leucocidin has been isolated from beta hemolytic streptococci, but not from other species of bacteria studied. 2. It does not give rise to antibodies, but precipitates immune sera against hemolytic streptococci, and is therefore a hapten. 3. A highly purified sample of S. H. up to a dilution of 1:128,000 hemolyzes red blood cells. Its hemolytic activity is not spe...

Rabbits immunized intravenously with living culture or nucleoproteins of non-hemolytic streptococci react to subsequent intracutaneous inoculations with homologous streptococci with smaller and harder lesions than are shown by normal animals similarly inoculated; and they do not develop the general manifestations of hypersensitiveness such as are shown by animals previously inoculated into the ...

Objective(s): Streptococcus pyogenes produces extracellular hyaluronidase enzyme. This enzyme is directly associated with the spread of the organism during infection. The objective of the present study was to clone and express the nucleotide sequence of the enzyme which is involved in hyaluronidase enzymatic activity. Materials and Methods: The enzymatic region of hyaluronidase gene was detecte...

Using the complement fixation reaction with whole bacterial solutions as antigens, it has been possible to confirm the existence, within the non-hemolytic streptococcus family, of two great groups. One of these groups, that which may be designated as of the left side, is related in an orderly way to the hemolytic streptococci; the other of the right side, is similarly related to the entire pneu...

In a previous paper (Lewandowski and Stahly, 1944) it was shown that the growth rate of a group C hemolytic streptococcus, adapted to artificial media, became constant after a number of subcultures in an apparently favorable medium. It is the purpose of this paper to give a description of the materials and methods used and to present the growth rates of a group of strains maintained by passage ...

Background.  The importance of bacteria other than group A streptococci (GAS) in different clinical presentations of cellulitis is unclear, commonly leading to treatment with broad-spectrum antibiotics. The aim of this study was to describe the etiological and clinical spectrum of cellulitis and identify clinical features predicting streptococcal etiology. Methods.  We prospectively enrolled 21...

Introduction: Hemolytic streptococci are one of the most frequent human pathogens capable of producing a variety of diseases ranging from pharyngitis, impetigo, to more severe and life threatening diseases like Toxic Shock Syndrome, neonatal sepsis, pneumonia and meningitis. Though they are still susceptible to commonly used antibiotics, resistance is increasingly reported. Materials and Method...

The antibacterial activity of the new penem compound HRE 664 was evaluated in 451 clinical isolates, including ampicillin-resistant members of the family Enterobacteriaceae, Acinetobacter spp., Haemophilus influenzae, Staphylococcus aureus, and beta-hemolytic streptococci, and compared with those of piperacillin, ceftazidime, ceftriaxone, aztreonam, imipenem, and the penem compound Sch 34343. T...

A test employing three fluorogenic 4-methylumbelliferyl substrates and the lectin of Dolichos biflorus was developed for the identification of beta-hemolytic streptococcal colonies associated with throat cultures. This non-serological method is unique in that it permits the accurate identification of groups C, F, and G streptococci, as well as groups A and B streptococci. The method is rapid, s...