Background Chronic liver diseases can be associated with autoimmune diseases. their association hemolytic anemia (AIHA) is poorly studied. Objectives Our objective was to study the prevalence and characteristics of AIHA in chronic Methods We performed a retrospective analysis data from consecutive patients followed our department for recruited January 2010 December 2019. The diagnosis AHAI reta...

We have investigated the hemolytic mechanisms in a patient with acquired immune hemolytic anemia whose red cells appeared to be coated with IgA alone. The clinical course was similar to that of patients with hemolytic anemia mediated by warm-reacting IgG antibody. Splenic sequestration of red cells was demonstrated, and marked reduction of hemolysis occurred after corticosteroid therapy. Antibo...

Drug-induced hemolytic anemia is an immune-mediated phenomenon that leads to the destruction of red blood cells. Here, we present a case of life-threatening ceftriaxone-induced hemolytic anemia (CIHA) in a previously healthy 3-year-old girl. We also reviewed the literature to summarize the clinical features and treatment of hemolytic anemia. Acute hemolysis is a rare side effect of ceftriaxone ...

Studies have indicated that sports anemia is mainly associated with intravascular hemolysis induced by exercise. We hypothesized that such exercise-induced hemolysis leads to oxidative damage due to an increase in free iron caused by hematocyte destruction. Thirty-one male ICR mice were randomly divided into 3 groups: a rested control group, an intense-exercise group, and a group rested for 24 ...

BACKGROUND Autoimmune hemolytic anemia is rare in children. First-line therapies for this disease consist of corticosteroids and intravenously administered immunoglobulin that are effective in most patients. However, a small proportion of cases (5 to 10%) is refractory to these therapies and may represent a medical emergency, especially when hemolysis is due to warm immunoglobulin M. Recently, ...

Concurrent hemolysis in patients with vitamin B12 deficiency is a well-recognized phenomenon and has been attributed to intramedullary destruction of erythrocytes (ineffective erythropoiesis). Recent studies revealed that homocysteine increased the risk of hemolysis in vitamin B12 deficiency in vitro and there is a high frequency (30%) of vitamin B12 deficiency in asymptomatic patients with hom...

The article by Levine et al.1 concerning abnormal liver chemistries and splenomegaly in intensively treated hemophiliacs left both observations unexplained. Although their literature search “revealed no reports of splenomegaly associated with hemophilia,” I would like to call attention to a 1966 report from our clinic on therapy of hemophilia with fraction I in which splenomegaly was observed a...

AN!) EUGENE P. CRoNKIT1 T HE anemia produced by whole body exposure to lethal doses of ionizing radiations develops more rapidly than would be expected from cessation of erythropoiesis t.ogether w’ith the normal attrition of cells. In large measure the excess loss of red cells is accounted for by hemorrhage, incident to the t.hrombocytopenia which occurs as the result of bone marrow aplasia. It...

BACKGROUND AND OBJECTIVES Intravenous Ig (IVIG) is used in renal transplantation for desensitization and treatment of antibody-mediated rejection (AMR). The infusion of high-dose IVIG is generally well tolerated, but there are reports of hemolytic anemia induced by anti-blood group antibodies present in IVIG. Here, we report our experience with IVIG-induced hemolytic anemia (IH) in ESRD patient...

A 61-year-old man presented with consistent hemolytic anemia 15 months after ascending and total arch replacement for DeBakey I type acute aortic dissection. The cause of hemolysis turned out to be mechanical damage of red blood cells at the inverted felt of the proximal anastomosis. Reoperation of resection of the felt and repair of the proximal anastomosis successfully resolved this problem. ...