نتایج جستجو برای: hemoglobinuria

تعداد نتایج: 2365  

Journal: :Haematologica 2010
Stella Santarone Andrea Bacigalupo Antonio M Risitano Elena Tagliaferri Erminia Di Bartolomeo Anna Paola Iori Alessandro Rambaldi Emanuele Angelucci Alessandra Spagnoli Federico Papineschi Stefania Tamiazzo Marta Di Nicola Paolo Di Bartolomeo

BACKGROUND Paroxysmal nocturnal hemoglobinuria is an acquired clonal disorder of the hemopoietic stem cells for which the only curative treatment is allogeneic hematopoietic stem cell transplantation. DESIGN AND METHODS The aim of this retrospective study was to assess the long-term clinical and hematologic results in 26 paroxysmal nocturnal hemoglobinuria patients who received hematopoietic ...

Journal: :Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 1985
M Okuno K Kawai E Tomita T Kano T Takai Y Muto R Kannagi

概要 慢 性経過 を示 した特発 性発作性 寒冷血 色素尿症 の1成 人例を報 告 し,文 献 的考察 を加 え た.症 例 は41才,男 性.1978年 冬期,先 行す る熱性疾 患を伴 わず,寒 冷に曝露 した後暗 褐色尿 に気 付 き,以 後毎年同 様 の症状 を繰 り返 すため, 1984年1月 精査 目的にて 当科 入院.貧 血 な し, 肝脾 腫 な し.入 院時検査 所見 で,ヘ モ グロ ビン尿(+), Ehrlich指 試験(+), Rosenbach試 験 (+), Donath-Landsteiner試 験(+),抗 体価4倍 で あ り発 作性寒冷 血色素 尿症 と診 断 した.血 清梅 毒反応(-), TPHA(-)で,血 清抗体価 は マイ コプラス マ,ム ンプス,麻 疹,単 純ヘ ル ペス, EBウ イル スいずれ も陰性 ない し低値 を示 した.経...

Journal: :Blood 1995
K Nafa P J Mason P Hillmen L Luzzatto M Bessler

Paroxysmal nocturnal hemoglobinuria is an acquired hemolytic anemia associated with somatic mutations in the X-linked gene PIG-A, which encodes a protein involved in the biosynthesis of glycosyl phosphatidylinositol anchors. To further elucidate the molecular basis of paroxysmal nocturnal hemoglobinuria, we have worked out a systematic and relatively rapid methodology to scan for mutations in t...

Journal: :Blood 1969
D Holden H Lichtman

T HE OCCURENCE of impaired marrow function in paroxysmal nocturnal hemoglobinuria (PNH) has long been recognized. A smaller group of patients, with an initial diagnosis of aplastic anemia, have been noted to develop signs of PNH during the course of their illness.1 Such persons have been said to have “the aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome.”2 Also evident, in some case...

Journal: :Blood 1952
J J VAN LOGHEM D E M DE LEON H FRENKEL-TIETZ M VAN DER HART

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