β- thalassemia major is a common hemoglobinopathy in humans. in some journals, numerous studies have reported different prevalence of hepatitis c among β- thalassemia major because thalassemic patients need multiple blood transfusions and blood transfusion is a common transmission pathway for hepatitis c virus. thus this study was performed for detection of anti-hcv between β- thalassemia major...

Most structurally abnormal hemoglobins are present in smaller amounts than HbA in the erythrocytes of heteroxygous subjects. In the presence of a hemoglobinopathy, a and globin synthesis remains balanced with equal production of the two types of chains. In reticulocytes of subjects with Hb Leiden (fi6 or 7 glu 0) there is greater production of a than fi globin in vitro (fl/a = 0.67), and slight...

Hb South Florida is a rare hemoglobin beta chain variant that is not associated with any clinical disorder. We report a heterozygous Hb South Florida [β1(NA1)Val>Met, GTG>ATG; HBB:c.4G>A] case determined during a premarital screening program. This hemoglobin variant can be identified with high performance liquid chromatography analysis confirmed with DNA sequencing. We emphasize in our study th...

Heterozygous hemoglobin sickle cell disease (HbSC) is the second most frequent hemoglobinopathy behind SCA [1]. Individuals with HbSC are heterozygous having received the βC-gene for hemoglobin C from one parent and the βS-gene for hemoglobin S from the other parent [2,3]. HbSC red cells contain equal levels of HbS and HbC. The blood smears of individuals with HbSC contain primarily Target cell...