Eight thousand seven hundred and thirty-six pregnant women were screened for thalassemia and hemoglobinopathies by mean corpuscular volume less than 80 femtolitres (fl). Three thousand six hundred and seventy women (42%) were MCV less than 80 fl. In this group there were 2,390 women (70%) who had positive Hb typing by high performance liquid chromatography (HPLC) such as beta-thalassemia major,...

To report a rare interaction between known pathogenic alpha variant (--SEA deletion) with another variant, Hb Ube-2 [α68 (E17) Asn →Asp] among our population. This finding may support the current classification of as benign or likely variant. date, limited data available in literature describing this abnormal hemoglobin compound heterozygous state Identification patient confirmed that these var...

Chronic Kidney Disease (CKD) will cause anemia which can lead to death. CKD patients undergoing hemodialysis therapy also experience anemia. Therefore, it is necessary check the erythrocyte index consisting of Mean Corpuscular Volume (MCV), Hemoglobin (MCH), and Concentration (MCHC) determine type so that appropriate be given. Objectives: To determined description in at H. Adam Malik General Ho...

Haemophilus influenzae requires an exogenous heme source for aerobic growth in vitro. Hemoglobin or hemoglobin-haptoglobin satisfies this requirement. Heme acquisition from hemoglobin-haptoglobin is mediated by proteins encoded by hgp genes. Both Hgps and additional proteins, including those encoded by the hxu operon, provide independent pathways for hemoglobin utilization. Recently we showed t...

With the technical assistance of Kaniil Tanrikulu H EMOGLOBIN E has been found with variable frequency among peopies of southeast Asia, such as the Thais,’ ’” the Burmese,2 the Malasians,3 the Indonesians,4 ”4’ the Bengalis,5#{176}’5” and Filipinos,6 and Vcddas of Ceylon.T37h Sporadic cases have been encountered in other countries.6’8 In 1955 an example of the hemoglobin E trait was discovered ...

Whole blood samples of patients with various forms of alpha thalassemia including hemoglobin H disease, alpha thalassemia trait, and the "silent carrier" state were incubated with leucine-(14)C for definition of relative rates of production of alpha and beta chains in these disorders. The chains were separated by carboxymethyl cellulose chromatography in the presence of 8 M urea and dithiothrei...

Background  H syndrome is an autosomal recessive genodermatosis with a low prevalence which is caused by a mutation in SLC29A3 gene. This disorder is characterized by sclerotic, hyperpigmented, hypertrichotic cutaneous plaques with systemic involvement including: hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, low height, and hyperglycemia. Case Presentation  Here we have pres...