98 ­ Each human kidney contains about 1 million functional units that remove wastes from the blood, help control the body’s fluid balance, and regulate electrolyte balance. New research in mice could help explain how kidneys generate the correct number of functional units, called nephrons, during development. (Left panel) Mice treated to have fewer nephron progenitor cells (bottom) during devel...

OBJECTIVE Fungal infection is a significant problem, causing of infective deaths of leukemic patients. The situation in developing countries is not well documented. The purpose of this study was characterizing IFD by analyzing data retrospectively to determine the incidence, predisposing factors, diagnostic methods, efficacy of treatment, and the outcome in pediatric patients with hematological...

UNLABELLED Splenectomy is the best available treatment for severe forms of hereditary spherocytosis, idiopathic thrombocytopenic purpura, and other hematologic conditions when these prove refractory to conservative management. It has been employed for many decades with low mortality and favorable remission rates. The use of laparoscopic splenectomy in recent years has been rapidly and even enth...

background: cornus mas l, an olive-shaped red-colored single-seeded fruit, is used in traditional medicine in different parts of europe and asia. objectives: in the present study, 40 male wistar rats were randomly divided into five groups, and the effects of 21 days of intraperitoneally (ip) administration of 50, 200 and 400 mg/kg body weight of c. mas hydro-methanolic extract on the rats hemat...

BACKGROUND AND OBJECTIVES Iron status has implications for normal erythrocyte and leukocyte function and for platelet count, size and activation. Increased storage of iron is considered a potential risk factor participating in the pathogenesis of malignant diseases. Since HFE gene mutations have recently been implicated in unbalanced iron homeostasis, we set out to examine the prevalence of the...

Cancer is a leading cause of death and disability in sub-Saharan Africa and will eclipse infectious diseases within the next several decades if current trends continue. Hematologic malignancies, including non-Hodgkin lymphoma, leukemia, Hodgkin lymphoma, and multiple myeloma, account for nearly 10% of the overall cancer burden in the region, and the incidence of non-Hodgkin lymphoma and Hodgkin...

BACKGROUND/AIMS Hepatic or splenic lesions in hematologic patients are not defined well because they are not easy to evaluate due to limitations of invasive procedures. Management typically depends on the clinical diagnosis with few microbiological data. METHODS We reviewed the medical records of consecutive hematologic patients with hepatic or splenic lesions in the infectious diseases unit ...

Prenatal diagnosis of hematologic diseases can now be performed with fetal blood, fetal amniotic fluid cell DNA, and fetal chorionic villi DNA. Some hemoglobinopathies can be detected by all three methods, and the choice will depend on the available obstetric and laboratory techniques, as well as the time of presentation of the pregnancy. Hopefully, further development of molecular probes and t...

Methods This study included patients who were hospitalized in Dokuz Eylul University Hospital Internal Medicine Intensive Care Unit for more than 24 hours during January 2012-December 2013 interval. The patients were divided into three groups; patients with solid tumors, patients with hematologic malignancies, and patiens without cancer. Their data was analyzed retrospectively. All patients ́ da...