نتایج جستجو برای: hemagglutinin neuraminidase gene

تعداد نتایج: 1151308  

2016
Li-Gang Chen Yuan-Sheng Liu Tang-Hui Zheng Xu Chen Ping Li Chuan-Xing Xiao Jian-Lin Ren

A total of ~38.6 million mortalities occur due to liver cancer annually, worldwide. Although a variety of therapeutic methods are available, the efficacy of treatment at present is extremely limited due to an increased risk of malignancy and inherently poor prognosis of liver cancer. Gene therapy is considered a promising option, and has shown notable potential for the comprehensive therapy of ...

2012
Maximilian Wei-Lin Popp Roos A. Karssemeijer Hidde L. Ploegh

The influenza virus uses the hemagglutinin (HA) and neuraminidase (NA) glycoproteins to interact with and infect host cells. While biochemical and microscopic methods allow examination of the early steps in flu infection, the genesis of progeny virions has been more difficult to follow, mainly because of difficulties inherent in fluorescent labeling of flu proteins in a manner compatible with l...

Journal: :Antiviral therapy 2010
Guillermo Ruiz-Carrascoso Inmaculada Casas Francisco Pozo Marta González-Vincent Pilar Pérez-Breña

In this study, we report a case of multidrug-resistant influenza A(H3N2) virus isolated from an immunosuppressed patient with prolonged viral shedding. We also describe the genetic characterization of the haemagglutinin, neuraminidase and M2 influenza genes. The virus contained the substitutions E119V in neuraminidase and V27A in M2, which produce resistance to oseltamivir and adamantanes, resp...

Journal: :Journal of virology 1987
K L van Wyke Coelingh C C Winter E D Jorgensen B R Murphy

The hemagglutinin-neuraminidase (HN) gene sequence was determined for 16 antigenic variants of human parainfluenza virus type 3 (PIV3). The variants were selected by using monoclonal antibodies (MAbs) to the HN protein which inhibit neuraminidase, hemagglutination, or both activities. Each variant had a single-point mutation in the HN gene, coding for a single amino acid substitution in the HN ...

Journal: :Vaccines 2023

Vaccination is an efficient approach to preventing influenza virus infections. Recently, we developed A and B vaccine backbones that increased the yield of several viruses in Madin–Darby canine kidney (MDCK) African green monkey (Vero) cells. These also viral replication embryonated chicken eggs, which are most frequently used platform for manufacturing. In this study, further increase titers i...

Journal: :Small 2021

Understanding how influenza viruses traverse the mucus and recognize host cells is critical for evaluating their zoonotic potential, prevention treatment of disease. The surface A virus covered with receptor-binding protein hemagglutinin receptor-cleaving enzyme neuraminidase, which jointly control interactions between cell. These proteins are organized in closely spaced trimers tetramers to fa...

Journal: :Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2010
I G Barr L Cui N Komadina R T Lee R T Lin Y Deng N Caldwell R Shaw S Maurer-Stroh

Pandemic H1N1 influenza virus is of global health concern and is currently the predominant influenza virus subtype circulating in the southern hemisphere 2010 winter. The virus has changed little since it emerged in 2009, however, in this report we describe several genetically distinct changes in the pandemic H1N1 influenza virus. These variants were first detected in Singapore in early 2010 an...

2011
Wendy A. Howard Steve C. Essen Benjamin W. Strugnell Christine Russell Laura Barrass Scott M. Reid Ian H. Brown

Surveillance for influenza virus in pigs in the United Kingdom during spring 2010 detected a novel reassortant influenza virus. This virus had genes encoding internal proteins from pandemic (H1N1) 2009 virus and hemagglutinin and neuraminidase genes from swine influenza virus (H1N2). Our results demonstrate processes contributing to influenza virus heterogeneity.

2003
ELLEN D. JORGENSEN

The hemagglutinin-neuraminidase (HN) gene sequence was determined for 16 antigenic variants of human parainfluenza virus type 3 (PIV3). The variants were selected by using monoclonal antibodies (MAbs) to the HN protein which inhibit neuraminidase, hemagglutination, or both activities. Each variant had a single-point mutation in the HN gene, coding for a single amino acid substitution in the HN ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید