نتایج جستجو برای: hemagglutinin h7
تعداد نتایج: 14871 فیلتر نتایج به سال:
Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when co...
The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously been associated with a switch in receptor specificity from avian-type (NeuAcα2-3Gal) to human-type (NeuAcα2-6Gal), as documented for the avian progenit...
Specific changes in immune repertoires at genetic level responding to the lethal H7N9 virus are still poorly understood. We performed deep sequencing on the T and B cells from patients recently infected with H7N9 to explore the correlation between clinical outcomes and immune repertoire alterations. T and B cell repertoires display highly dynamic yet distinct clonotype alterations. During infec...
Comparisons of residues between sub-types of influenza virus is increasingly used to assess the zoonotic potential of a circulating strain and for comparative studies across subtypes. An analysis of N-terminal cleavage sites for thirteen subtypes of influenza A hemagglutinin (HA) sequences, has previously been described by Nobusawa and colleagues. We have expanded this analysis for the eighteen...
The hemagglutinin (HA) and neuraminidase (NA) genes of H7 avian influenza virus (AIV) isolated between 1994 and 2002 from live-bird markets (LBMs) in the northeastern United States and from three outbreaks in commercial poultry have been characterized. Phylogenetic analysis of the HA and NA genes demonstrates that the isolates from commercial poultry were closely related to the viruses circulat...
Avian influenza virus (AIV) infection is a major cause of bird or human mortality and morbidity, therefore the rapid identification of the virus is of important clinical and epidemiological implication. Methods: A multiplex Reverse Transcriptase PCR (RT-PCR) was optimized for the detection of influenza A virus and the H5 and H9 subtypes. The influenza type A specific primers were directed to t...
کلی فرمها واشریشیا کلی دارای نقش مهمی در کیفیت مواد غذایی از جمله شیر هستند و حضور آنها در این ماده بعنوان شاخص آلودگی مدفوعی در نظر گرفته می شود. سویه اشریشیا کلی o157:h7 به عنوان یکی از عمده ترین سویه های بیماری زای این باکتری میباشد که از طریق مواد غذایی با منشا دامی به انسان منتقل می شود. این مطالعه بر روی 175 نمونه شیر مخزن و 64 نمونه انفرادی شیر گاو دچار ورم پستان تحت بالینی در شهر مشهد ب...
background and aims: influenza (flu) is a respiratory infection in mammals and birds. it is caused by an rna virus in the family orthomyxoviridae. the virus is divided into three main types. influenza virus type a is found in a wide variety of bird and mammal species and can undergo major shifts in immunological properties. hemagglutinin (ha) is an important influenza virus surface antigen that...
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