Sulfonamides are the first effective chemotherapeutic agents used for several years to cure or prevent systemic bacterial infections. In addition, this agents showed anti-carbonic anhydrase and cause cell cycle perturbation in the G1 phase, disruption of microtubule assembly, suppression of the transcription activator Nf-Y, angiogenesis and matrix metalloproteinase (MMP). In recent years, novel...

Tungsten has no known function in humans and is a relatively new contaminant, whereas molybdenum, its congener the periodic table, nutritionally essential element. In addition to early studies on molybdosis ruminants, their toxic effects form of tungstate molybdate have been addressed primarily rodents are predominantly mediated by inducing oxidative stress various tissues. The purpose this stu...

We synthesized and evaluated three novel series of substituted benzophenones for their allosteric modulation the human K v 11.1 (hERG) channel. compared effects with reference compound LUF7346 previously shown to shorten action potential cardiomyocytes derived from stem cells. Most compounds behaved as negative modulators (NAMs) [ 3 H]dofetilide binding Compound 9i was most potent amongst all l...

cervical cancer is the most common gynecologic cancer and the second most common cancer in women worldwide. herbal preparations are used to treat cancer for centuries. the aim of this study was investigate the cytotoxic effects of the methanol extract of citrullus colocynthis and volatile oils of iranian c. medica on hela cell line. after preparation extract and volatile oils, different concent...

Cyclic acetals of ethylene glycol, cis-but-2-ene-1,4-diol and their dichlorocyclopropyl derivatives were synthesized. Compounds simultaneously containing the gem-dichlorocyclopropane 1,3-dioxacycloalkane cycles are shown to exhibit cytotoxic activity against HEK293, SH-SY5Y, HepG2, MCF-7, A549, Jurkat cell lines. The obtained results open up prospects for further studies antitumor 2-(2,2-dichlo...

Sulfonamides are the first effective chemotherapeutic agents used for several years to cure or prevent systemic bacterial infections. In addition, this agents showed anti-carbonic anhydrase and cause cell cycle perturbation in the G1 phase, disruption of microtubule assembly, suppression of the transcription activator Nf-Y, angiogenesis and matrix metalloproteinase (MMP). In recent years, novel...

Nano-silver (AgNP) has biological properties which are significant for consumer products, food technology, textiles and medical applications (e.g. wound care products, implantable medical devices, in diagnosis, drug delivery, and imaging). For their antibacterial activity, silver nanoparticles are largely used in various commercially available products. Thus, the use of nano-silver is becoming ...

Nano-silver (AgNP) has biological properties which are significant for consumer products, food technology, textiles and medical applications (e.g. wound care products, implantable medical devices, in diagnosis, drug delivery, and imaging). For their antibacterial activity, silver nanoparticles are largely used in various commercially available products. Thus, the use of nano-silver is becoming ...

isolation of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant for their anti-tumor effects. it has been reported that several species of conifers posses’ cytotoxic activities on some tumor cell lines. here branchlets and berries of juniperus foetidissima and j. sabina were collected, dried and ethanol extracts of them obtained u...

Background & Aims: Verapamil as a calcium channel blocker has been broadly used in the treatment of many cardiovascular diseases such as hypertension and arrhythmia. Furthermore, the anti-tumor/ antiinflammatory effects of verapamil have been shown. In the present study, the cytotoxic effect of verapamil on human peripheral blood mononuclear cells (PBMCs) and BALB/c peritoneal macrophges has be...