Leon, Lisa R., Michael D. Blaha, and David A. DuBose. Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery. J Appl Physiol 100: 1400–1409, 2006. First published October 20, 2005; doi:10.1152/japplphysiol.01040.2005.—Elevated circulating cytokines are observed in heatstroke patients, suggesting a role for these substances in the pathophysiologi...

[no abstract available]

This study was performed to gain insights into novel therapeutic approaches for the treatment of heatstroke. The central nervous system regulates peripheral immune responses via the vagus nerve, the primary neural component of the cholinergic anti-inflammatory pathway. Electrical vagus nerve stimulation (VNS) reportedly suppresses pro-inflammatory cytokine release in several models of inflammat...

Bacterial meningitis can be difficult to recognize: the meningeal triad symptoms are not always present and the alteration in mental status can mimic heatstroke. Escherichia coli meningitis is a serious disease whose early diagnosis, appropriate antibiotic treatment, and hemodynamic management are essential.

The two common forms of heat illness in the Services are heatstroke and heat exhaustion. Biochemical predisposing factors are considered for each. Susceptibility to malignant hyperthermia should be tested for in cases of heat stroke. The heterozygote status for cystic fibrosis should be established in cases of heat exhaustion.