Computational studies have recently gained significant interest in engineering applications for the virtual monitoring of bone pathologies such as osteoporosis and fracture healing. Several authors have investigated numerically the role of quantitative ultrasound as a diagnostic and monitoring tool of the fracture healing process since ultrasonic techniques are non-invasive and non-ionizing mea...

Although the methods of reduction and fixation of fractures Have been constantly changing since the days of Hippocrates the method of healing has never changed, and never will. It takes a very considerable force to fracture a normal bone: If the bone breaks after a trivial accident the fracture is said to be Pathological. Bone shows an exception from the normal healing of other structures which...

In direct fracture healing no or just a minimal amount of external callus is formed. The strain in the fracture gap is low enough to allow direct bone formation. This can only occur in anatomically reconstructed fractures that are rigidly stabilized. In indirect fracture healing, new bone is formed by transformation of fibrous tissue or cartilaginous tissue (endochondral bone formation). This o...

OBJECTIVES Healing in cancellous metaphyseal bone might be different from midshaft fracture healing due to different access to mesenchymal stem cells, and because metaphyseal bone often heals without a cartilaginous phase. Inflammation plays an important role in the healing of a shaft fracture, but if metaphyseal injury is different, it is important to clarify if the role of inflammation is als...

Concomitant traumatic brain injury (TBI) and long bone fracture are commonly observed in multitrauma and polytrauma. Despite clinical observations of enhanced bone healing in patients with TBI, the relationship between TBI and fracture healing remains poorly understood, with clinical data limited by the presence of several confounding variables. Here we developed a novel trauma model featuring ...

BACKGROUND Osteoporosis is characterized by low bone mass, bone fragility and increased susceptibility to fracture. Fracture healing in osteoporosis is delayed and rates of implant failure are high with few biological treatment options available. This study aimed to determine whether a single dose of bone morphogenetic protein-7 (BMP-7) in a collagen/carboxy-methyl cellulose (CMC) composite enh...

INTRODUCTION The biological process of fracture healing is complex with influences that are both patient-dependent and related to the trauma experienced and stability of the fracture. Fracture healing complications negatively affect the patient's quality of life, even more when fractures occur in the elderly osteoporotic patients. AREAS COVERED In the polytherapy for bone regeneration, a high...

While it is well known that the presence of lymphocytes and cytokines are important for fracture healing, the exact role of the various cytokines expressed by cells of the immune system on osteoblast biology remains unclear. To study the role of inflammatory cytokines in fracture repair, we studied tibial bone healing in wild-type and Rag1(-/-) mice. Histological analysis, µCT stereology, biome...

PURPOSES The objective of this study was to investigate the role of stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, on bone healing and whether SDF-1 contributes to accelerating bone repair in traumatic brain injury (TBI)/fracture model. MATERIALS AND METHODS Real-time polymerase chain reaction and immunohistochemical analysis were used to detect the expression of SDF-1 during ...

OBJECTIVE The purpose of this study was to investigate chemokine profiles and their functional roles in the early phase of fracture healing in mouse models. METHODS The expression profiles of chemokines were examined during fracture healing in wild-type (WT) mice using a polymerase chain reaction array and histological staining. The functional effect of monocyte chemotactic protein-1 (MCP-1) ...